首页> Acta pharmacologica Sinica> Intracerebellar upregulation of Rheb(S16H) ameliorates motor dysfunction in mice with SCA2.

Intracerebellar upregulation of Rheb(S16H) ameliorates motor dysfunction in mice with SCA2.

导出 OA

翻译打印收藏纠错

第一作者： Sehwan,Kim

第一单位： School of Life Science and Biotechnology, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.;Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41404, Republic of Korea.

作者： Sehwan,Kim ^[1] ; Junwoo,Park ^[2] ; Hyemi,Eo ^[2] ; Gi Beom,Lee ^[2] ; Se Min,Park ^[2] ; Minsang,Shin ^[3] ; Seung Eun,Lee ^[4] ; Youngpyo,Nam ^[5] ; Sang Ryong,Kim ^[6]

作者单位： School of Life Science and Biotechnology, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.;Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41404, Republic of Korea. ^[1] School of Life Science and Biotechnology, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea. ^[2] Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41404, Republic of Korea.;Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea. ^[3] Research Animal Resource Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea. ^[4] Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41404, Republic of Korea. blackpyo2@knu.ac.kr. ^[5] School of Life Science and Biotechnology, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea. srk75@knu.ac.kr.;Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41404, Republic of Korea. srk75@knu.ac.kr. ^[6]

关键词 AAV1-Rheb(S16H)cerebellar ataxia mTORC1 motor dysfunction neuroprotection neurotrophic factor