A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.
第一作者:
Songmi,Lee
第一单位:
Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
作者:
Songmi,Lee [1]
;
Clint L,Miller [2]
;
Amy R,Bentley [3]
;
Michael R,Brown [4]
;
Pavithra,Nagarajan [5]
;
Raymond,Noordam [6]
;
John,Morrison [7]
;
Karen,Schwander [8]
;
Kenneth,Westerman [9]
;
Minjung,Kho [10]
;
Aldi T,Kraja [11]
;
Paul S,de Vries [4]
;
Farah,Ammous [12]
;
Hughes,Aschard [13]
;
Traci M,Bartz [14]
;
Anh,Do [15]
;
Charles T,Dupont [16]
;
Mary F,Feitosa [8]
;
Valborg,Gudmundsdottir [17]
;
Xiuqing,Guo [18]
;
Sarah E,Harris [19]
;
Keiko,Hikino [20]
;
Zhijie,Huang [21]
;
Christophe,Lefevre [22]
;
Leo-Pekka,Lyytikäinen [23]
;
Yuri,Milaneschi [24]
;
Giuseppe Giovanni,Nardone [25]
;
Aurora,Santin [25]
;
Helena,Schmidt [26]
;
Botong,Shen [27]
;
Tamar,Sofer [5]
;
Quan,Sun [28]
;
Ye An,Tan [29]
;
Jingxian,Tang [30]
;
Sébastien,Thériault [31]
;
Peter J,van der Most [32]
;
Erin B,Ware [12]
;
Stefan,Weiss [33]
;
Wang,Ya Xing [34]
;
Chenglong,Yu [35]
;
Wei,Zhao [12]
;
Md Abu Yusuf,Ansari [36]
;
Pramod,Anugu [37]
;
John R,Attia [38]
;
Lydia A,Bazzano [21]
;
Joshua C,Bis [14]
;
Max,Breyer [39]
;
Brian,Cade [5]
;
Guanjie,Chen [3]
;
Stacey,Collins [12]
;
Janie,Corley [19]
;
Gail,Davies [19]
;
Marcus,Dörr [40]
;
Jiawen,Du [28]
;
Todd L,Edwards [41]
;
Tariq,Faquih [5]
;
Jessica D,Faul [12]
;
Alison E,Fohner [14]
;
Amanda M,Fretts [42]
;
Srushti,Gangireddy [43]
;
Adam,Gepner [44]
;
MariaElisa,Graff [45]
;
Edith,Hofer [46]
;
Georg,Homuth [33]
;
Michelle M,Hood [47]
;
Xu,Jie [34]
;
Mika,Kähönen [48]
;
Sharon Lr,Kardia [47]
;
Carrie A,Karvonen-Gutierrez [47]
;
Lenore J,Launer [49]
;
Daniel,Levy [50]
;
Maitreiyi,Maheshwari [51]
;
Lisa W,Martin [52]
;
Koichi,Matsuda [53]
;
John J,McNeil [35]
;
Ilja M,Nolte [32]
;
Tomo,Okochi [54]
;
Laura M,Raffield [55]
;
Olli T,Raitakari [56]
;
Lorenz,Risch [57]
;
Martin,Risch [58]
;
Ana Diez,Roux [59]
;
Edward A,Ruiz-Narvaez [60]
;
Tom C,Russ [19]
;
Takeo,Saito [54]
;
Pamela J,Schreiner [61]
;
Rodney J,Scott [38]
;
James,Shikany [62]
;
Jennifer A,Smith [12]
;
Harold,Snieder [32]
;
Beatrice,Spedicati [25]
;
E Shyong,Tai [29]
;
Adele M,Taylor [19]
;
Kent D,Taylor [18]
;
Paola,Tesolin [25]
;
Rob M,van Dam [29]
;
Rujia,Wang [32]
;
Wei,Wenbin [63]
;
Tian,Xie [32]
;
Jie,Yao [18]
;
Kristin L,Young [45]
;
Ruiyuan,Zhang [21]
;
Alan B,Zonderman [27]
;
Biobank Japan Project [64]
;
Lifelines Cohort Study [65]
;
Maria Pina,Concas [19]
;
David,Conen [27]
;
Simon R,Cox [37]
;
Michele K,Evans [15]
;
Ervin R,Fox [41]
;
Lisa,de Las Fuentes [25]
;
Ayush,Giri [66]
;
Giorgia,Girotto [15]
;
Hans J,Grabe [17]
;
Charles,Gu [47]
;
Vilmundur,Gudnason [38]
;
Sioban D,Harlow [67]
;
Elizabeth,Holliday [35]
;
Jonas B,Jost [10]
;
Paul,Lacaze [23]
;
Seunggeun,Lee [21]
;
Terho,Lehtimäki [30]
;
Changwei,Li [4]
;
Ching-Ti,Liu [45]
;
Alanna C,Morrison [24]
;
Kari E,North [47]
;
Brenda Wjh,Penninx [8]
;
Patricia A,Peyser [14]
;
Michael M,Province [5]
;
Bruce M,Psaty [68]
;
Susan,Redline [3]
;
Frits R,Rosendaal [18]
;
Charles N,Rotimi [46]
;
Jerome I,Rotter [29]
;
Reinhold,Schmidt [69]
;
Xueling,Sim [12]
;
Chikashi,Terao [70]
;
David R,Weir [71]
;
Xiaofeng,Zhu [72]
;
Nora,Franceschini [73]
;
Jeffrey R,O'Connell [5]
;
Cashell E,Jaquish [51]
;
Heming,Wang [74]
;
Alisa,Manning [15]
;
Patricia B,Munroe [4]
;
Dabeeru C,Rao [7]
;
Han,Chen [75]
;
W James,Gauderman [76]
;
Laura,Bierut [1]
;
Thomas W,Winkler ;
Myriam,Fornage
作者单位:
Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
[1]
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
[2]
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
[3]
Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX.
[4]
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
[5]
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden.
[6]
Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA.
[7]
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO.
[8]
Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA.
[9]
Graduate School of Data Science, Seoul National University, Seoul.
[10]
University of Mississippi Medical Center, Jackson, MS.
[11]
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.
[12]
Department of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris.
[13]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
[14]
Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO.
[15]
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
[16]
Icelandic Heart Association, Kopavogur.
[17]
The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
[18]
Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh.
[19]
Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa.
[20]
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
[21]
Department of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW.
[22]
Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Tampere University, Tampere.
[23]
Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam.
[24]
Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste.
[25]
Department of Molecular Biology and Biochemistry, Medical University Graz, Graz, Styria.
[26]
Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD.
[27]
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
[28]
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
[29]
Department of Biostatistics, Boston University School of Public Health, Boston, MA.
[30]
Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, QC.
[31]
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen.
[32]
Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald.
[33]
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, Beijing.
[34]
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC.
[35]
Department of Data Science, University of Mississippi Medical Center, Jackson, MS.
[36]
Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
[37]
School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW.
[38]
Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
[39]
German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald.
[40]
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
[41]
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA.
[42]
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
[43]
Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
[44]
Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
[45]
Department of Neurology, Medical University Graz, Graz, Styria.
[46]
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
[47]
Finnish Cardiovascular Research Center - Tampere, Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere.
[48]
Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
[49]
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
[50]
Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA.
[51]
Department of Cardiology, George Washington University, Washington, DC.
[52]
Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo.
[53]
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi.
[54]
Department of Genetics, University of North Carolina, Chapel Hill, NC.
[55]
Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, InFLAMES Research Flagship, Turku University Hospital and University of Turku, Turku.
[56]
Faculty of Medical Sciences , Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Vaduz.
[57]
Central Laboratory, Cantonal Hospital Graubünden, Chur.
[58]
Urban Health Collaborative, Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA.
[59]
Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI.
[60]
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
[61]
Division of General Internal Medicine and Population Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
[62]
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, Beijing.
[63]
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste.
[64]
Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON.
[65]
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Western Pomerania.
[66]
Rothschild Foundation Hospital, Institut Français de Myopie, Paris.
[67]
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden.
[68]
The Clinical Research Center at Shizuoka General Hospital, Shizuoka.
[69]
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
[70]
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
[71]
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
[72]
Division of Cardiovascular Science, Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
[73]
Clinical Pharmacology and Precision Medicine, Queen Mary University of London, London.
[74]
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.
[75]
Department of Genetic Epidemiology, University of Regensburg, Regensburg.
[76]
DOI
10.21203/rs.3.rs-6025759/v1
PMID
40034430
发布时间
2026-01-30
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