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A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.

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第一作者: Songmi,Lee
第一单位: Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
作者: Songmi,Lee [1] ; Clint L,Miller [2] ; Amy R,Bentley [3] ; Michael R,Brown [4] ; Pavithra,Nagarajan [5] ; Raymond,Noordam [6] ; John,Morrison [7] ; Karen,Schwander [8] ; Kenneth,Westerman [9] ; Minjung,Kho [10] ; Aldi T,Kraja [11] ; Paul S,de Vries [4] ; Farah,Ammous [12] ; Hughes,Aschard [13] ; Traci M,Bartz [14] ; Anh,Do [15] ; Charles T,Dupont [16] ; Mary F,Feitosa [8] ; Valborg,Gudmundsdottir [17] ; Xiuqing,Guo [18] ; Sarah E,Harris [19] ; Keiko,Hikino [20] ; Zhijie,Huang [21] ; Christophe,Lefevre [22] ; Leo-Pekka,Lyytikäinen [23] ; Yuri,Milaneschi [24] ; Giuseppe Giovanni,Nardone [25] ; Aurora,Santin [25] ; Helena,Schmidt [26] ; Botong,Shen [27] ; Tamar,Sofer [5] ; Quan,Sun [28] ; Ye An,Tan [29] ; Jingxian,Tang [30] ; Sébastien,Thériault [31] ; Peter J,van der Most [32] ; Erin B,Ware [12] ; Stefan,Weiss [33] ; Wang,Ya Xing [34] ; Chenglong,Yu [35] ; Wei,Zhao [12] ; Md Abu Yusuf,Ansari [36] ; Pramod,Anugu [37] ; John R,Attia [38] ; Lydia A,Bazzano [21] ; Joshua C,Bis [14] ; Max,Breyer [39] ; Brian,Cade [5] ; Guanjie,Chen [3] ; Stacey,Collins [12] ; Janie,Corley [19] ; Gail,Davies [19] ; Marcus,Dörr [40] ; Jiawen,Du [28] ; Todd L,Edwards [41] ; Tariq,Faquih [5] ; Jessica D,Faul [12] ; Alison E,Fohner [14] ; Amanda M,Fretts [42] ; Srushti,Gangireddy [43] ; Adam,Gepner [44] ; MariaElisa,Graff [45] ; Edith,Hofer [46] ; Georg,Homuth [33] ; Michelle M,Hood [47] ; Xu,Jie [34] ; Mika,Kähönen [48] ; Sharon Lr,Kardia [47] ; Carrie A,Karvonen-Gutierrez [47] ; Lenore J,Launer [49] ; Daniel,Levy [50] ; Maitreiyi,Maheshwari [51] ; Lisa W,Martin [52] ; Koichi,Matsuda [53] ; John J,McNeil [35] ; Ilja M,Nolte [32] ; Tomo,Okochi [54] ; Laura M,Raffield [55] ; Olli T,Raitakari [56] ; Lorenz,Risch [57] ; Martin,Risch [58] ; Ana Diez,Roux [59] ; Edward A,Ruiz-Narvaez [60] ; Tom C,Russ [19] ; Takeo,Saito [54] ; Pamela J,Schreiner [61] ; Rodney J,Scott [38] ; James,Shikany [62] ; Jennifer A,Smith [12] ; Harold,Snieder [32] ; Beatrice,Spedicati [25] ; E Shyong,Tai [29] ; Adele M,Taylor [19] ; Kent D,Taylor [18] ; Paola,Tesolin [25] ; Rob M,van Dam [29] ; Rujia,Wang [32] ; Wei,Wenbin [63] ; Tian,Xie [32] ; Jie,Yao [18] ; Kristin L,Young [45] ; Ruiyuan,Zhang [21] ; Alan B,Zonderman [27] ; Biobank Japan Project [64] ; Lifelines Cohort Study [65] ; Maria Pina,Concas [19] ; David,Conen [27] ; Simon R,Cox [37] ; Michele K,Evans [15] ; Ervin R,Fox [41] ; Lisa,de Las Fuentes [25] ; Ayush,Giri [66] ; Giorgia,Girotto [15] ; Hans J,Grabe [17] ; Charles,Gu [47] ; Vilmundur,Gudnason [38] ; Sioban D,Harlow [67] ; Elizabeth,Holliday [35] ; Jonas B,Jost [10] ; Paul,Lacaze [23] ; Seunggeun,Lee [21] ; Terho,Lehtimäki [30] ; Changwei,Li [4] ; Ching-Ti,Liu [45] ; Alanna C,Morrison [24] ; Kari E,North [47] ; Brenda Wjh,Penninx [8] ; Patricia A,Peyser [14] ; Michael M,Province [5] ; Bruce M,Psaty [68] ; Susan,Redline [3] ; Frits R,Rosendaal [18] ; Charles N,Rotimi [46] ; Jerome I,Rotter [29] ; Reinhold,Schmidt [69] ; Xueling,Sim [12] ; Chikashi,Terao [70] ; David R,Weir [71] ; Xiaofeng,Zhu [72] ; Nora,Franceschini [73] ; Jeffrey R,O'Connell [5] ; Cashell E,Jaquish [51] ; Heming,Wang [74] ; Alisa,Manning [15] ; Patricia B,Munroe [4] ; Dabeeru C,Rao [7] ; Han,Chen [75] ; W James,Gauderman [76] ; Laura,Bierut [1] ; Thomas W,Winkler ; Myriam,Fornage
作者单位: Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX. [1] Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA. [2] Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. [3] Human Genetics Center, Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX. [4] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA. [5] Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden. [6] Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA. [7] Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO. [8] Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA. [9] Graduate School of Data Science, Seoul National University, Seoul. [10] University of Mississippi Medical Center, Jackson, MS. [11] Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI. [12] Department of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris. [13] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA. [14] Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO. [15] Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN. [16] Icelandic Heart Association, Kopavogur. [17] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA. [18] Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh. [19] Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa. [20] Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA. [21] Department of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW. [22] Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Tampere University, Tampere. [23] Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam. [24] Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste. [25] Department of Molecular Biology and Biochemistry, Medical University Graz, Graz, Styria. [26] Laboratory of Epidemiology and Population Sciences, Health Disparities Research Section, National Institute on Aging, National Institutes of Health, Baltimore, MD. [27] Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC. [28] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. [29] Department of Biostatistics, Boston University School of Public Health, Boston, MA. [30] Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, QC. [31] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen. [32] Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald. [33] Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, Beijing. [34] School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC. [35] Department of Data Science, University of Mississippi Medical Center, Jackson, MS. [36] Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS. [37] School of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW. [38] Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. [39] German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald. [40] Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. [41] Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA. [42] Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN. [43] Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. [44] Cardiovascular Disease (CVD) Genetic Epidemiology Laboratory, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC. [45] Department of Neurology, Medical University Graz, Graz, Styria. [46] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI. [47] Finnish Cardiovascular Research Center - Tampere, Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere. [48] Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD. [49] Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. [50] Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA. [51] Department of Cardiology, George Washington University, Washington, DC. [52] Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo. [53] Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi. [54] Department of Genetics, University of North Carolina, Chapel Hill, NC. [55] Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, InFLAMES Research Flagship, Turku University Hospital and University of Turku, Turku. [56] Faculty of Medical Sciences , Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Vaduz. [57] Central Laboratory, Cantonal Hospital Graubünden, Chur. [58] Urban Health Collaborative, Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA. [59] Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI. [60] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN. [61] Division of General Internal Medicine and Population Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL. [62] Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, Beijing. [63] Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste. [64] Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON. [65] Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Western Pomerania. [66] Rothschild Foundation Hospital, Institut Français de Myopie, Paris. [67] Department of Clinical Epidemiology, Leiden University Medical Center, Leiden. [68] The Clinical Research Center at Shizuoka General Hospital, Shizuoka. [69] Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio. [70] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC. [71] Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD. [72] Division of Cardiovascular Science, Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. [73] Clinical Pharmacology and Precision Medicine, Queen Mary University of London, London. [74] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO. [75] Department of Genetic Epidemiology, University of Regensburg, Regensburg. [76]
DOI 10.21203/rs.3.rs-6025759/v1
PMID 40034430
发布时间 2026-01-30
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