换一批Natural product Pulsatilla saponin D sensitizes BRCA-proficient ovarian cancers to PARP inhibitors through inhibiting homologous recombination repair.
第一作者：
Shengbin,Lin
第一单位：
School of Biopharmacy, China Pharmaceutical University, Nanjing, P.R. China.;Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
作者：
医学主题词
人类(Humans);皂苷类(Saponins);女(雌)性(Female);卵巢肿瘤(Ovarian Neoplasms);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);白头翁属(Pulsatilla);BRCA1蛋白质(BRCA1 Protein);小鼠(Mice);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);小鼠, 裸(Mice, Nude);BRCA2蛋白质(BRCA2 Protein);DNA断裂, 双链(DNA Breaks, Double-Stranded);生物制品(Biological Products);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);小鼠, 近交BALB C(Mice, Inbred BALB C)
DOI
10.1093/jpp/rgaf006
PMID
40036611
发布时间
2025-05-10
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