首页> European journal of medicinal chemistry> Design and biochemical evaluation of 2-cyclopropyl-thioureidobenzamide (CP-TBA) derivatives as potent HBV capsid assembly modulators targeting a novel binding site.

Design and biochemical evaluation of 2-cyclopropyl-thioureidobenzamide (CP-TBA) derivatives as potent HBV capsid assembly modulators targeting a novel binding site.

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第一作者： Mei,Wang

第一单位： School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong, China; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, 250012, Shandong, China.

作者： Mei,Wang ^[1] ; Yutong,Dou ^[2] ; Aixin,Li ^[3] ; Zechun,Yang ^[4] ; Minghui,Liang ^[4] ; Yuanyuan,Liu ^[4] ; Yong,Xie ^[5] ; Liyan,Wang ^[6] ; Yuqing,Cai ^[7] ; Yunfu,Chen ^[5] ; Peng,Xue ^[8] ; Xin,Wang ^[9] ; Zhuanchang,Wu ^[10] ; Peng,Zhan ^[11] ; Haiyong,Jia ^[12]

作者单位： School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong, China; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, 250012, Shandong, China. ^[1] Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, 250012, Shandong, China. ^[2] School of Laboratory Medicine, Shandong Second Medical University, Weifang, 261053, China. ^[3] School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong, China. ^[4] State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co., Ltd, Dongguan, 523871, Guangdong. China. ^[5] Research Center for Medical and Structural Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong Universityy, Jinan, 250012, Shandong, China. ^[6] School of Public Health, Shandong Second Medical University, Weifang, 261053, Shandong, China. ^[7] School of Public Health, Shandong Second Medical University, Weifang, 261053, Shandong, China. Electronic address: jplxp26@126.com. ^[8] Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, Shandong, China. Electronic address: coala07@163.com. ^[9] Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, 250012, Shandong, China. Electronic address: zhuanchangwu@sdu.edu.cn. ^[10] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, 250012, Shandong, China. Electronic address: zhanpeng1982@sdu.edu.cn. ^[11] School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong, China. Electronic address: 502378774@163.com. ^[12]

关键词 Capsid assembly modulators HBV Solvent-exposed region Structure-based drug design Thioureidobenzamides