Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.

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第一作者： Chao,Qi

第一单位： MRC Laboratory of Molecular Biology, Cambridge, UK.

作者： Chao,Qi ^[1] ; Sofia,Lövestam ^[1] ; Alexey G,Murzin ^[1] ; Sew,Peak-Chew ^[1] ; Catarina,Franco ^[1] ; Marika,Bogdani ^[2] ; Caitlin,Latimer ^[2] ; Jill R,Murrell ^[3] ; Patrick W,Cullinane ^[4] ; Zane,Jaunmuktane ^[4] ; Thomas D,Bird ^[2] ; Bernardino,Ghetti ^[5] ; Sjors H W,Scheres ^[6] ; Michel,Goedert ^[7]

作者单位： MRC Laboratory of Molecular Biology, Cambridge, UK. ^[1] Departments of Neurology and Pathology, University of Washington, Seattle, WA, USA.;Veterans Administration Puget Sound Health Care System, Seattle, WA, USA. ^[2] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Pathology and Laboratory Medicine, Children's Hospital of the University of Pennsylvania, Philadelphia, PA, USA. ^[3] Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College, London, UK.;Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College, London, UK. ^[4] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. ^[5] MRC Laboratory of Molecular Biology, Cambridge, UK. scheres@mrc-lmb.cam.ac.uk. ^[6] MRC Laboratory of Molecular Biology, Cambridge, UK. mg@mrc-lmb.cam.ac.uk. ^[7]

DOI 10.1038/s41594-025-01498-5

PMID 40044789

发布时间 2025-03-11

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Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.

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Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.

Nature structural & molecular biology

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