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Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance.

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第一作者： Taylor K,Watson

第一单位： Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.

作者： Taylor K,Watson ^[1] ; Aaron B I,Rosen ^[2] ; Travis,Drow ^[1] ; Jacob A,Medjo ^[1] ; Matthew A,MacQuivey ^[1] ; Yan,Ge ^[3] ; H Denny,Liggitt ^[4] ; Dane A,Grosvenor ^[5] ; Kimberly A,Dill-McFarland ^[5] ; Matthew C,Altman ^[5] ; Patrick J,Concannon ^[6] ; Jane H,Buckner ^[7] ; David J,Rawlings ^[8] ; Eric J,Allenspach ^[9]

作者单位： Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA. ^[1] Joint CMU-Pitt PhD Program in Computational Biology, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA.;Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA. ^[2] Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL.;International Center for Genetic Engineering and Biotechnology, China Regional Research Center, Taizhou, China. ^[3] Department of Comparative Medicine, University of Washington, Seattle, WA. ^[4] Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA. ^[5] Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL. ^[6] Benaroya Research Institute, Seattle, WA. ^[7] Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.;Department of Pediatrics, University of Washington, Seattle, WA.;Department of Immunology, University of Washington, Seattle, WA. ^[8] Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.;Department of Pediatrics, University of Washington, Seattle, WA. ^[9]