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Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C.

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第一作者： Linquan,Li

第一单位： School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China; School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China.

作者： Linquan,Li ^[1] ; Xi,Gu ^[2] ; Jingyi,Meng ^[3] ; Yiming,Wen ^[4] ; Jing,Yi ^[5] ; Fengqian,Xu ^[6] ; Li,Zhang ^[7] ; Sulin,Zhang ^[8] ; Zhili,Zuo ^[9]

作者单位： School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China; School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China. ^[1] University of Chinese Academy of Sciences, Beijing 100049, China. ^[2] Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. ^[3] School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. ^[4] School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China. ^[5] School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China; College of Pharmacy, Chengdu Medical College, Chengdu, Sichuan, 610500, China. ^[6] School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China. Electronic address: zhangli@suse.edu.cn. ^[7] Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: slzhang@simm.ac.cn. ^[8] School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China; School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China. Electronic address: zlzuo@ucas.ac.cn. ^[9]

关键词 Drug design Structural modification Synthesis p53 Y220C