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In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection.

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第一作者： Dustin,Williams

第一单位： Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA.;Bone and Biofilm Research Lab, University of Utah, Salt Lake City, UT, USA.;Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.;Department of Pathology, University of Utah, Salt Lake City, UT, USA.;Department of Physical Medicine and Rehabilitation, Uniformed Services University, Bethesda, MD, USA.;Purgo Scientific, South Jordan, UT, USA.

作者： Dustin,Williams ^[1] ; David,Rothberg ^[2] ; Walker,Kay ^[3] ; Lisa,Nehring ^[4] ; Robert,Falconer ^[5] ; Richard Tyler,Epperson ^[2] ; Brooke,Kawaguchi ^[2] ; Carolyn,Ardizzone ^[6] ; Brian,Barnum ^[7] ; Nicholas,Ashton ^[2]

作者单位： Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA.;Bone and Biofilm Research Lab, University of Utah, Salt Lake City, UT, USA.;Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.;Department of Pathology, University of Utah, Salt Lake City, UT, USA.;Department of Physical Medicine and Rehabilitation, Uniformed Services University, Bethesda, MD, USA.;Purgo Scientific, South Jordan, UT, USA. ^[1] Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA.;Bone and Biofilm Research Lab, University of Utah, Salt Lake City, UT, USA.;Purgo Scientific, South Jordan, UT, USA. ^[2] Noorda College of Osteopathic Medicine, Provo, UT, USA. ^[3] Rocky Vista University School of Osteopathic Medicine, St. George, UT, USA. ^[4] Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA.;Bone and Biofilm Research Lab, University of Utah, Salt Lake City, UT, USA.;Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. ^[5] School of Medicine, University of New Mexico, Albuquerque, NM, USA. ^[6] Purgo Scientific, South Jordan, UT, USA. ^[7]

关键词 Biofilm Infection Open fracture Orthopedic Sheep model Sustainable drug delivery

DOI 10.1016/j.bioflm.2025.100262

PMID 40059987

发布时间 2025-03-11

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In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection.

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In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection.

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