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Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19.

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第一作者: Jimmy Tsz Hang,Lee
第一单位: Wellcome Sanger Institute, Hinxton, UK.
作者单位: Wellcome Sanger Institute, Hinxton, UK. [1] National Heart and Lung Institute, Imperial College London, London, UK.;British Heart Foundation Centre of Research Excellence, Imperial College London, London, UK. [2] York Biomedical Research Institute, Hull York Medical School, University of York, York, UK. [3] Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK. [4] The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. [5] National Heart and Lung Institute, Imperial College London, London, UK. [6] Wellcome Sanger Institute, Hinxton, UK.;European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL), Cambridge, UK. [7] Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. [8] Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy. [9] Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, London, UK. [10] European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL), Cambridge, UK. [11] Department of Infectious Disease, Imperial College London, London, UK. [12] National Heart and Lung Institute, Imperial College London, London, UK.;London Metropolitan University, London, UK. [13] Wellcome Sanger Institute, Hinxton, UK.;Cambridge Stem Cell Institute & Department of Medicine, University of Cambridge, Cambridge, UK. [14] Biosciences Institute and Innovation, Methodology and Application Research Theme, Newcastle University, Newcastle upon Tyne, UK. [15] Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK. a.j.fisher@newcastle.ac.uk.;Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. a.j.fisher@newcastle.ac.uk. [16] The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mhemberg@bwh.harvard.edu. [17] National Heart and Lung Institute, Imperial College London, London, UK. m.noseda@imperial.ac.uk.;British Heart Foundation Centre of Research Excellence, Imperial College London, London, UK. m.noseda@imperial.ac.uk. [18] Wellcome Sanger Institute, Hinxton, UK. ob5@sanger.ac.uk. [19]
DOI 10.1038/s41467-025-56473-x
PMID 40064844
发布时间 2025-05-12
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