The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.

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第一作者： Onur Kerem,Tever

第一单位： Institute for Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany.

作者： Onur Kerem,Tever ^[1] ; Torben,Mentrup ^[1] ; Ivan Kingyue,Chinn ^[2] ; Hitoshi,Ishikuma ^[1] ; Regina,Fluhrer ^[3] ; Marc,Schmitz ^[4] ; Rebekka,Wehner ^[4] ; Rayk,Behrendt ^[5] ; Javier,Chinen ^[2] ; Bernd,Schröder ^[6]

作者单位： Institute for Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany. ^[1] Department of Pediatrics, Division of Immunology, Allergy, and Retrovirology, Baylor College of Medicine and Texas Children's Hospital, Houston and The Woodlands, USA. ^[2] Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.;Center for Interdisciplinary Health Research, University of Augsburg, Augsburg, Germany.;Center for Advanced Analytics and Predictive Sciences (CAAPS), University of Augsburg, Augsburg, Germany. ^[3] Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.;National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.;German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[4] Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany. ^[5] Institute for Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Medizinisch-Theoretisches Zentrum MTZ, Technische Universität Dresden, Fiedlerstraße 42, 01307, Dresden, Germany. bernd.schroeder@tu-dresden.de. ^[6]

关键词 Aicardi-Goutières syndrome Cytosolic DNA degradation ER-associated protein degradation Intramembrane proteolysis Signal peptide peptidase cGAS/STING pathway