换一批Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.
第一作者：
Cecilia R,Chambers
第一单位：
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.
作者：
Cecilia R,Chambers [1]
;
Supitchaya,Watakul [2]
;
Peter,Schofield [3]
;
Anna E,Howell [2]
;
Jessie,Zhu [1]
;
Alice M H,Tran [2]
;
Nadia,Kuepper [2]
;
Daniel A,Reed [1]
;
Kendelle J,Murphy [1]
;
Lily M,Channon [2]
;
Brooke A,Pereira [1]
;
Victoria M,Tyma [2]
;
Victoria,Lee [2]
;
Michael,Trpceski [1]
;
Jake,Henry [3]
;
Pauline,Melenec [2]
;
Lea,Abdulkhalek [2]
;
Max,Nobis [4]
;
Xanthe L,Metcalf [2]
;
Shona,Ritchie [1]
;
Antonia,Cadell [5]
;
Janett,Stoehr [2]
;
Astrid,Magenau [1]
;
Diego,Chacon-Fajardo [5]
;
Jessica L,Chitty [1]
;
Savannah,O'Connell [6]
;
Anaiis,Zaratzian [2]
;
Michael,Tayao [2]
;
Andrew,Da Silva [2]
;
Ruth J,Lyons [2]
;
Leonard D,Goldstein [7]
;
Ashleigh,Dale [8]
;
Alexander,Rookyard [8]
;
Angela,Connolly [8]
;
Ben,Crossett [8]
;
Yen T H,Tran [9]
;
Peter,Kaltzis [9]
;
Claire,Vennin [1]
;
Marija,Dinevska [10]
;
Australian Pancreatic Cancer Genome Initiative (APGI) [11]
;
Australian Pancreatic Cancer Matrix Atlas (APMA) [12]
;
David R,Croucher [12]
;
Jaswinder,Samra [6]
;
Anubhav,Mittal [13]
;
Robert J,Weatheritt [9]
;
Andrew,Philp [14]
;
Gonzalo,Del Monte-Nieto [1]
;
Lei,Zhang [1]
;
Ronaldo F,Enriquez [1]
;
Thomas R,Cox [15]
;
Yan-Chuan C,Shi [16]
;
Mark,Pinese [17]
;
Nicola,Waddell [18]
;
Hao-Wen,Sim [19]
;
Tatyana,Chtanova [11]
;
Yingxiao,Wang [20]
;
Anthony M,Joshua [21]
;
Lorraine,Chantrill [22]
;
Thomas R Jeffry,Evans [21]
;
Anthony J,Gill [11]
;
Jennifer P,Morton [3]
;
Marina,Pajic [14]
;
Daniel,Christ [1]
;
Herbert,Herzog [1]
;
Paul,Timpson ;
David,Herrmann
作者单位：
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.
[1]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
[2]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;Immune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
[3]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
[4]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;Translational Oncology Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
[5]
Immune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
[6]
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;Data Science Platform, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
[7]
Sydney Mass Spectrometry, University of Sydney, Sydney, New South Wales, Australia.
[8]
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia.
[9]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia.;Department of Surgery, University of Melbourne, Melbourne, Australia.
[10]
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;Translational Oncology Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
[11]
Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
[12]
Centre for Healthy Ageing, Centenary Institute, Sydney, New South Wales, Australia.;School of Sport, Exercise and Rehabilitation Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.
[13]
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;St. Vincent's Centre for Applied Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
[14]
School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.
[15]
QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
[16]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.;NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.
[17]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia.
[18]
Department of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.;Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
[19]
Department of Medical Oncology and Illawarra Shoalhaven Local Health District, Wollongong, New South Wales, Australia.
[20]
Cancer Research UK Scotland Institute, Glasgow, UK.;School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.
[21]
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.;Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.;Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
[22]
医学主题词
胰腺肿瘤(Pancreatic Neoplasms);动物(Animals);受体, 神经肽Y(Receptors, Neuropeptide Y);神经肽Y(Neuropeptide Y);人类(Humans);信号传导(Signal Transduction);小鼠(Mice);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);细胞系, 肿瘤(Cell Line, Tumor);肝肿瘤(Liver Neoplasms);肿瘤转移(Neoplasm Metastasis);疾病模型, 动物(Disease Models, Animal);突变(Mutation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);小鼠, 基因敲除(Mice, Knockout);细胞运动(Cell Movement);精氨酸(Arginine)
DOI
10.1126/sciadv.adq4416
PMID
40073121
发布时间
2025-05-13
- 浏览0
Science advances
Science advances
2025年11卷11期
eadq4416页
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