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ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma.

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第一作者： Dhana Sekhar Reddy,Bandi

第一单位： Department of Hematology and Oncology, O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama, Birmingham, AL, 35233, USA.

作者： Dhana Sekhar Reddy,Bandi ^[1] ; Ganji Purnachandra,Nagaraju ^[1] ; Sujith,Sarvesh ^[1] ; Julienne L,Carstens ^[1] ; Jeremy B,Foote ^[2] ; Emily C,Graff ^[3] ; Yu-Hua D,Fang ^[4] ; Adam B,Keeton ^[5] ; Xi,Chen ^[5] ; Jacob,Valiyaveettil ^[5] ; Kristy L,Berry ^[6] ; Sejong,Bae ^[7] ; Mehmet,Akce ^[1] ; Greg,Gorman ^[8] ; Karina J,Yoon ^[9] ; Upender,Manne ^[10] ; Michael R,Boyd ^[11] ; Donald J,Buchsbaum ^[12] ; Asfar S,Azmi ^[13] ; Yulia Y,Maxuitenko ^[6] ; Gary A,Piazza ^[5] ; Bassel F,El-Rayes ^[14]

作者单位： Department of Hematology and Oncology, O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama, Birmingham, AL, 35233, USA. ^[1] Department of Microbiology, University of Alabama, Birmingham, AL, 35294, USA. ^[2] Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, 36849, USA. ^[3] Radiology and Neurology, University of Alabama, Birmingham, AL, 35233, USA. ^[4] Drug Discovery and Development Department, Harrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.;ADT Pharmaceuticals, LLC, Orange Beach, AL, 31691, USA. ^[5] Drug Discovery and Development Department, Harrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA. ^[6] Division of General Internal Medicine and Population Science, University of Alabama School of Medicine, Birmingham, AL, 35233, USA. ^[7] Department of Pharmaceutical, Social and Administrative Sciences, Samford University, Birmingham, AL, 35229, USA. ^[8] Department of Pharmacology and Toxicology, University of Alabama, Birmingham, AL, 35233, USA.;Department of Cell, Developmental and Integrative Biology, University of Alabama, Birmingham, AL, 35294, USA. ^[9] Department of Pathology, University of Alabama, Birmingham, AL, 35233, USA. ^[10] ADT Pharmaceuticals, LLC, Orange Beach, AL, 31691, USA. ^[11] Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, 35233, USA. ^[12] Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA. ^[13] Department of Hematology and Oncology, O'Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama, Birmingham, AL, 35233, USA. belrayes@uabmc.edu. ^[14]

关键词 KRAS Pancreatic ductal adenocarcinoma RAS-driven malignancies Tumor immune microenvironment pan-RAS inhibitor