Supercharging CAR-T cells through transcriptional and epigenetic armoring.

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第一作者： Diyuan,Qin

第一单位： Cancer Center, Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.;Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A ∗ STAR), Singapore 138673, Singapore.

作者： Diyuan,Qin ^[1] ; Yanna,Lei ^[2] ; Pei,Shu ^[3] ; Yugu,Zhang ^[2] ; Yuin-Han,Loh ^[4] ; Yongsheng,Wang ^[5] ; Qijing,Li ^[6]

作者单位： Cancer Center, Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.;Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A ∗ STAR), Singapore 138673, Singapore. ^[1] Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ^[2] Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ^[3] Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A ∗ STAR), Singapore 138673, Singapore. ^[4] Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.;Cancer Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ^[5] Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A ∗ STAR), Singapore 138673, Singapore.;Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.;Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore. ^[6]

关键词 CAR-T cells epigenetic modification exhaustion and memory differentiation transcriptional regulation in immunotherapy tumor microenvironment