首页> Stem cells (Dayton, Ohio)> SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids.

SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids.

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第一作者： Mathilde,Colinet

第一单位： Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège 4000, Belgium.

作者： Mathilde,Colinet ^[1] ; Ioana,Chiver ^[1] ; Antonela,Bonafina ^[1] ; Gérald,Masset ^[1] ; Daniel,Almansa ^[1] ; Emmanuel,Di Valentin ^[2] ; Jean-Claude,Twizere ^[3] ; Laurent,Nguyen ^[4] ; Ira,Espuny-Camacho ^[5]

作者单位： Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège 4000, Belgium. ^[1] GIGA Viral Vector Platform, GIGA Institute, University of Liège, Liège 4000, Belgium. ^[2] Laboratory of Viral Interactomes, Unit of Molecular Biology of Diseases, GIGA Institute, University of Liège, Liège 4000, Belgium. ^[3] Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège 4000, Belgium.;WELBIO Department, WEL Research Institute, Wavre 1300, Belgium. ^[4] Laboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, Liège 4000, Belgium.;GIGA HIPS, GIGA Institute, University of Liège, Liège 4000, Belgium. ^[5]

关键词 SARS-CoV2 brain infectivity astrogliosis human cortical organoids inflammatory and cell survival mechanisms

医学主题词人类(Humans);类器官(Organoids);星形细胞(Astrocytes);神经胶质增生(Gliosis);炎症(Inflammation);神经元(Neurons);大脑皮质(Cerebral Cortex)

DOI 10.1093/stmcls/sxaf010

PMID 40103011

发布时间 2025-05-31

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