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Transfer RNA acetylation regulates in vivo mammalian stress signaling.

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第一作者： Supuni,Thalalla Gamage

第一单位： Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

作者： Supuni,Thalalla Gamage ^[1] ; Roxane,Khoogar ^[2] ; Shereen,Howpay Manage ^[1] ; Judey T,DaRos ^[1] ; McKenna C,Crawford ^[1] ; Joe,Georgeson ^[3] ; Bogdan V,Polevoda ^[4] ; Chelsea,Sanders ^[5] ; Kendall A,Lee ^[5] ; Kellie D,Nance ^[1] ; Vinithra,Iyer ^[3] ; Anatoly,Kustanovich ^[3] ; Minervo,Perez ^[1] ; Chu T,Thu ^[1] ; Sam R,Nance ^[1] ; Ruhul,Amin ^[6] ; Christine N,Miller ^[7] ; Ronald J,Holewinski ^[8] ; Sudipto,Das ^[8] ; Thomas J,Meyer ^[9] ; Vishal,Koparde ^[9] ; Acong,Yang ^[2] ; Parthav,Jailwala ^[9] ; Joe T,Nguyen ^[6] ; Thorkell,Andresson ^[8] ; Kent,Hunter ^[6] ; Shuo,Gu ^[2] ; Beverly A,Mock ^[6] ; Elijah F,Edmondson ^[10] ; Simone,Difilippantonio ^[5] ; Raj,Chari ^[7] ; Schraga,Schwartz ^[3] ; Mitchell R,O'Connell ^[4] ; Colin Chih-Chien,Wu ^[2] ; Jordan L,Meier ^[1]

作者单位： Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. ^[1] RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. ^[2] Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. ^[3] Department of Biochemistry and Biophysics, Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. ^[4] Animal Research Technical Support, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. ^[5] Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ^[6] Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD, USA. ^[7] Protein Mass Spectrometry Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. ^[8] CCR Collaborative Bioinformatics Resource (CCBR), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, USA. ^[9] Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. ^[10]

医学主题词动物(Animals);乙酰化作用(Acetylation);RNA, 转移(RNA, Transfer);信号传导(Signal Transduction);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);应激, 生理学(Stress, Physiological);核糖体(Ribosomes);人类(Humans);磷酰化(Phosphorylation);乙酰基转移酶类(Acetyltransferases);蛋白质生物合成(Protein Biosynthesis)

DOI 10.1126/sciadv.ads2923

PMID 40106564

发布时间 2025-05-30

基金项目

HHSN261201500003C/CA/NCI NIH HHS/United States ZIA BC011065/ImNIH/Intramural NIH HHS/United States R35 GM133462/GM/NIGMS NIH HHS/United States ZIA BC012037/ImNIH/Intramural NIH HHS/United States HHSN261200800001C/RC/CCR NIH HHS/United States HHSN261200800001E/CA/NCI NIH HHS/United States ZIA BC011488/ImNIH/Intramural NIH HHS/United States HHSN261201500003I/CA/NCI NIH HHS/United States

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