换一批Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease.
第一作者：
Jared M,Phillips
第一单位：
Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.;Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
作者：
Jared M,Phillips [1]
;
Logan C,Dumitrescu [2]
;
Derek B,Archer [2]
;
Alexandra N,Regelson [3]
;
Shubhabrata,Mukherjee [4]
;
Michael L,Lee [4]
;
Seo-Eun,Choi [4]
;
Phoebe,Scollard [4]
;
Emily H,Trittschuh [5]
;
Walter A,Kukull [6]
;
Sarah,Biber [6]
;
Jesse,Mez [7]
;
Emily R,Mahoney [3]
;
Michelle,Clifton [3]
;
Julia B,Libby [3]
;
Skylar,Walters [3]
;
William S,Bush [8]
;
Corinne D,Engelman [9]
;
Qiongshi,Lu [10]
;
David W,Fardo [11]
;
Keith F,Widaman [12]
;
Rachel F,Buckley [13]
;
Elizabeth C,Mormino [14]
;
R Elizabeth,Sanders [4]
;
Lindsay R,Clark [15]
;
Katherine A,Gifford [3]
;
Badri,Vardarajan [16]
;
Michael L,Cuccaro [17]
;
Margaret A,Pericak-Vance [18]
;
Lindsay A,Farrer [19]
;
Li-San,Wang [20]
;
Gerard D,Schellenberg [20]
;
Jonathan L,Haines [8]
;
Angela L,Jefferson [3]
;
Sterling C,Johnson [14]
;
Marilyn S,Albert [21]
;
C Dirk,Keene [22]
;
Andrew J,Saykin [23]
;
Shannon L,Risacher [23]
;
Eric B,Larson [24]
;
Reisa A,Sperling [25]
;
Richard,Mayeux [26]
;
Alison M,Goate [27]
;
Alan E,Renton [27]
;
Edoardo,Marcora [27]
;
Brian,Fulton-Howard [27]
;
Tulsi,Patel [27]
;
David A,Bennett [28]
;
Julie A,Schneider [28]
;
Lisa L,Barnes [28]
;
Carlos,Cruchaga [29]
;
Jason,Hassenstab [30]
;
Michael E,Belloy [30]
;
Shea J,Andrews [31]
;
Susan M,Resnick [32]
;
Murat,Bilgel [32]
;
Yang,An [32]
;
Lori L,Beason-Held [32]
;
Keenan A,Walker [32]
;
Michael R,Duggan [32]
;
Brandon S,Klinedinst [4]
;
Paul K,Crane [4]
;
Timothy J,Hohman [33]
作者单位：
Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.;Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
[1]
Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.;Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
[2]
Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
[3]
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
[4]
Department of Psychiatry and Behavior Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.;VA Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA 98108, USA.
[5]
National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
[6]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
[7]
Cleveland Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
[8]
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA.;Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.
[9]
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.;Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706, USA.;Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53706, USA.
[10]
Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY 40536, USA.;Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
[11]
Graduate School of Education, University of California at Riverside, Riverside, CA 92521, USA.
[12]
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.;Center of Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.;Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC 3010, Australia.
[13]
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
[14]
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.;Geriatric Research and Education Center, William S. Middleton Memorial Veteran's Hospital, Madison, WI 53705, USA.
[15]
Department of Neurology, Columbia University, New York, NY 10032, USA.;The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, NY 10032, USA.;The Institute of Genomic Medicine, Columbia University Medical Center and The New York Presbyterian Hospital, New York, NY 10032, USA.
[16]
John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL 33136, USA.;Dr John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, FL 33136, USA.
[17]
John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, FL 33136, USA.
[18]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.;Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02118, USA.
[19]
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
[20]
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
[21]
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
[22]
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.;Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.;Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
[23]
Department of Medicine, University of Washington, Seattle, WA 98195, USA.;Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
[24]
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.;Center of Alzheimer's Research and Treatment, Department of Neurology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.
[25]
Department of Neurology, Columbia University, New York, NY 10032, USA.;The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, NY 10032, USA.
[26]
Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.;Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
[27]
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
[28]
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.
[29]
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
[30]
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143, USA.
[31]
Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
[32]
Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.;Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.;Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
[33]
医学主题词
人类(Humans);阿尔茨海默病(Alzheimer Disease);男(雄)性(Male);老年人(Aged);女(雌)性(Female);老年人, 80以上(Aged, 80 and over);载脂蛋白E类(Apolipoproteins E);队列研究(Cohort Studies);中年人(Middle Aged);全基因组关联研究(Genome-Wide Association Study);衰老(Aging)
DOI
10.1093/brain/awaf106
PMID
40111762
发布时间
2025-09-28
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Brain
Brain
2714-2729页
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