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DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients' airway epithelial cells.

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第一作者： Marey,Messingschlager

第一单位： Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.;Freie Universität Berlin, Institute of Biology, Berlin, Germany.

作者： Marey,Messingschlager ^[1] ; Sebastian D,Mackowiak ^[2] ; Maria Theresa,Voelker ^[3] ; Matthias,Bieg ^[2] ; Jennifer,Loske ^[1] ; Robert Lorenz,Chua ^[2] ; Johannes,Liebig ^[2] ; Sören,Lukassen ^[2] ; Loreen,Thürmann ^[4] ; Anke,Seegebarth ^[4] ; Sven,Twardziok ^[2] ; Daria,Doncevic ^[5] ; Carl,Herrmann ^[5] ; Stephan,Lorenz ^[6] ; Sven,Klages ^[6] ; Fridolin,Steinbeis ^[7] ; Martin,Witzenrath ^[8] ; Florian,Kurth ^[9] ; Christian,Conrad ^[2] ; Leif E,Sander ^[8] ; Naveed,Ishaque ^[2] ; Roland,Eils ^[10] ; Irina,Lehmann ^[11] ; Sven,Laudi ^[3] ; Saskia,Trump ^[12]

作者单位： Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.;Freie Universität Berlin, Institute of Biology, Berlin, Germany. ^[1] Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany. ^[2] Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany. ^[3] Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany. ^[4] Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany. ^[5] Max Planck Institute for Molecular Genetics, Berlin, Germany. ^[6] Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany. ^[7] Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.;German Center for Lung Research (DZL), Giessen, Germany. ^[8] Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.;Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.;Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. ^[9] Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.;Health Data Science Unit, Heidelberg University Hospital and BioQuant, University of Heidelberg, Heidelberg, Germany.;German Center for Lung Research (DZL), Giessen, Germany.;Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany. ^[10] Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany.;German Center for Lung Research (DZL), Giessen, Germany. ^[11] Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, Molecular Epidemiology Unit, Berlin, Germany. saskia.trump@bih-charite.de. ^[12]

关键词 COVID-19 Nasal Mucosa Post-COVID-19 Condition Whole-genome DNA Methylation Sequencing scRNA-seq