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Dual inhibition of hepatic ACLY and ACSS2: A synergistic approach to combat NAFLD through lipogenesis reduction and mitochondrial enhancement.

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第一作者： Mengdi,Zhang

第一单位： School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

作者： Mengdi,Zhang ^[1] ; Jinliang,Ji ^[2] ; Yuanyuan,Lei ^[2] ; Fujian,Qin ^[3] ; Yitong,Tao ^[2] ; Ning,Li ^[4] ; Jinlei,Bian ^[5] ; Zhiyu,Li ^[6] ; Maode,Lai ^[7] ; Zhixia,Qiu ^[8]

作者单位： School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[1] Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[2] School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[3] National Experimental Teaching Demonstration Center of Pharmacy, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[4] Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ^[5] Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhiyuli@cpu.edu.cn. ^[6] School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Disease Proteomics of Zhejiang Province, Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China; Research Unit of Intelligence Classification of Tumor Pathology and Precision Therapy, Chinese Academy of Medical Sciences (2019RU042), Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: lmd@cpu.edu.cn. ^[7] Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zxqiu@cpu.edu.cn. ^[8]

关键词 ATP citrate lyase (ACLY)Acetyl-CoA Acyl-coenzyme A synthetase short-chain family member 2 (ACSS2)De novo lipogenesis (DNL)Fatty acid oxidation Non-alcoholic fatty liver disease (NAFLD)