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Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy.

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第一作者： Patrick W,Cullinane

第一单位： Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.;Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.;Queen Square Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.

作者： Patrick W,Cullinane ^[1] ; Yang,Yang ^[2] ; Viorica,Chelban ^[3] ; Yee Yen,Goh ^[3] ; Kirsten,Ebanks ^[4] ; Toby,Curless ^[4] ; Sarah,Wrigley ^[4] ; Eduardo,de Pablo-Fernández ^[4] ; Janice,Holton ^[5] ; Sew,Peak-Chew ^[6] ; Catarina,Franco ^[6] ; Amanda L,Woerman ^[7] ; Henry,Houlden ^[3] ; Thomas T,Warner ^[1] ; Sjors H W,Scheres ^[6] ; Michel,Goedert ^[6] ; Zane,Jaunmuktane ^[8]

作者单位： Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.;Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.;Queen Square Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK. ^[1] Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.;Department of Structural Biology, Van Andel Institute, Grand Rapids, Michigan, USA. ^[2] Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK. ^[3] Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.;Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. ^[4] Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. ^[5] Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. ^[6] Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, USA. ^[7] Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.;Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.;Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK. ^[8]

关键词 cell‐based seeding cryo‐EM frontotemporal lobar degeneration multiple system atrophy α‐synuclein