Evaluation of Complex Drug Interactions Between Elexacaftor-Tezacaftor-Ivacaftor and Statins Using Physiologically Based Pharmacokinetic Modeling.

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第一作者： Eunjin,Hong

第一单位： College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Gyeonggi-do, Republic of Korea.;Gradute School of Clinical Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Gyeonggi-do, Republic of Korea.

作者： Eunjin,Hong ^[1] ; Peter S,Chung ^[2] ; Adupa P,Rao ^[2] ; Paul M,Beringer ^[3]

作者单位： College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Gyeonggi-do, Republic of Korea.;Gradute School of Clinical Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Gyeonggi-do, Republic of Korea. ^[1] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA.;USC Anton Yelchin CF Clinic, 1510 San Pablo St., Los Angeles, CA 90033, USA. ^[2] USC Anton Yelchin CF Clinic, 1510 San Pablo St., Los Angeles, CA 90033, USA.;Department of Clinical Pharmacy, Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA. ^[3]

关键词 Statin cystic fibrosis (CF)cystic fibrosis transmembrane conductance regulator (CFTR) modulator cytochrome P450 isoenzymes (CYP)drug–drug interactions organic anion-transporting polypeptides (OATPs)physiologically based pharmacokinetic (PBPK)

DOI 10.3390/pharmaceutics17030318

PMID 40142982

发布时间 2025-03-29

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