首页> Frontiers in pharmacology> Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron-glia crosstalk in Alzheimer's disease.

Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron-glia crosstalk in Alzheimer's disease.

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第一作者： Artemizia,Évora

第一单位： Neuroinflammation, Signaling and Neuroregeneration, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.

作者： Artemizia,Évora ^[1] ; Gonçalo,Garcia ^[2] ; Ana,Rubi ^[1] ; Eleonora,De Vitis ^[3] ; Ana Teresa,Matos ^[1] ; Ana Rita,Vaz ^[2] ; Francesca,Gervaso ^[3] ; Giuseppe,Gigli ^[4] ; Alessandro,Polini ^[3] ; Dora,Brites ^[2]

作者单位： Neuroinflammation, Signaling and Neuroregeneration, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal. ^[1] Neuroinflammation, Signaling and Neuroregeneration, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.;Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal. ^[2] Institute of Nanotechnology, National Research Council (CNR Nanotec), Lecce, Italy. ^[3] Institute of Nanotechnology, National Research Council (CNR Nanotec), Lecce, Italy.;Dipartimento di Medicina Sperimentale, Università Del Salento, Lecce, Italy. ^[4]

关键词 Alzheimer’s disease modelling SH-SY5Y cells transfected with APP695 human neural tricultures miR-124-3p mimic miRNA-engineered exosomes microfluidic system neuron-glia communication

DOI 10.3389/fphar.2025.1474012

PMID 40144670

发布时间 2025-03-28

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