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Highly Precise Anomaly Detection Using Multivariate Statistical Process Control with Appropriate Scaling of Input Variables in Pharmaceutical Continuous Manufacturing.

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第一作者： Takuya,Oishi

第一单位： Research & Development Division, Powrex Corporation, 5-5-5 Kitagawara, Itami, Hyogo 664-0837, Japan.;Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.

作者： Takuya,Oishi ^[1] ; Takuya,Nagato ^[2] ; Chikara,Tsujikawa ^[3] ; Takuya,Minamiguchi ^[3] ; Sanghong,Kim ^[4]

作者单位： Research & Development Division, Powrex Corporation, 5-5-5 Kitagawara, Itami, Hyogo 664-0837, Japan.;Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. ^[1] Research & Development Division, Powrex Corporation, 5-5-5 Kitagawara, Itami, Hyogo 664-0837, Japan. ^[2] Department of Chemical Engineering, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku-Katsura, Nisikyo-ku, Kyoto 615-8510, Japan. ^[3] Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. ^[4]

关键词 anomaly detection fluidized bed drying multivariate statistical process control multiway principal component analysis pharmaceutical continuous manufacturing wet granulation

主题词多元分析(Multivariate Analysis);工艺学, 制药(Technology, Pharmaceutical);药用制剂(Pharmaceutical Preparations);模型, 统计学(Models, Statistical)

DOI 10.1248/cpb.c24-00652

PMID 40159234

发布时间 2025-03-30

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准确一般字义偏差语意偏离译文作用小提交