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Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation.

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第一作者： Anna,Solta

第一单位： Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria.

作者： Anna,Solta ^[1] ; Büsra,Ernhofer ^[1] ; Kristiina,Boettiger ^[1] ; Christian,Lang ^[2] ; Zsolt,Megyesfalvi ^[3] ; Theresa,Mendrina ^[4] ; Dominik,Kirchhofer ^[5] ; Gerald,Timelthaler ^[5] ; Beata,Szeitz ^[6] ; Melinda,Rezeli ^[7] ; Clemens,Aigner ^[1] ; Arvand,Haschemi ^[8] ; Lukas W,Unger ^[9] ; Balazs,Dome ^[10] ; Karin,Schelch ^[11]

作者单位： Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria. ^[1] Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria.;Division of Pulmonology, Department of Medicine II, Medical University of Vienna, Vienna, Austria. ^[2] Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria.;Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary.;National Koranyi Institute of Pulmonology, Budapest, Hungary. ^[3] Center for Cancer Research, Medical University of Vienna, Vienna, Austria.;Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria. ^[4] Center for Cancer Research, Medical University of Vienna, Vienna, Austria. ^[5] National Koranyi Institute of Pulmonology, Budapest, Hungary. ^[6] Department of Biomedical Engineering, Lund University, Lund, Sweden. ^[7] Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. ^[8] Deptartment of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.;Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria. ^[9] Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria. balazs.dome@meduniwien.ac.at.;Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary. balazs.dome@meduniwien.ac.at.;National Koranyi Institute of Pulmonology, Budapest, Hungary. balazs.dome@meduniwien.ac.at.;Department of Translational Medicine, Lund University, Lund, Sweden. balazs.dome@meduniwien.ac.at. ^[10] Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria. karin.schelch@meduniwien.ac.at.;Center for Cancer Research, Medical University of Vienna, Vienna, Austria. karin.schelch@meduniwien.ac.at. ^[11]

关键词 Metabolism Molecular subtypes Oxidative phosphorylation Small cell lung cancer

DOI 10.1186/s40170-025-00382-6

PMID 40165271

发布时间 2025-04-02

基金项目

FWF No. T 1062-B33, FWF I3522, FWF I3977 and I4677, Sonderforschungsbereich F83/Austrian Science Fund FWF No. T 1062-B33, FWF I3522, FWF I3977 and I4677, Sonderforschungsbereich F83/Austrian Science Fund FWF No. T 1062-B33, FWF I3522, FWF I3977 and I4677, Sonderforschungsbereich F83/Austrian Science Fund FWF No. T 1062-B33, FWF I3522, FWF I3977 and I4677, Sonderforschungsbereich F83/Austrian Science Fund 2020-1.1.6-JÖVŐ, TKP2021-EGA-33, FK-143751 and FK-147045, UNKP-20-3, UNKP-21-3 and UNKP-23-5, ÚNKP-22-3-II/Nemzeti Kutatási Fejlesztési és Innovációs Hivatal 2020-1.1.6-JÖVŐ, TKP2021-EGA-33, FK-143751 and FK-147045, UNKP-20-3, UNKP-21-3 and UNKP-23-5, ÚNKP-22-3-II/Nemzeti Kutatási Fejlesztési és Innovációs Hivatal 2020-1.1.6-JÖVŐ, TKP2021-EGA-33, FK-143751 and FK-147045, UNKP-20-3, UNKP-21-3 and UNKP-23-5, ÚNKP-22-3-II/Nemzeti Kutatási Fejlesztési és Innovációs Hivatal EFOP-3.6.3-VEKOP-16-2017-00009/Semmelweis Egyetem FBKS-2020-22-(291)/Fru Berta Kamprads Stiftelse 101131228-BIOSMALL/HORIZON EUROPE Framework Programme

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Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation.

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Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation.

Cancer & metabolism

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