首页> RSC advances> Design, nanogel synthesis, anti-proliferative activity and <i>in silico</i> ADMET profile of pyrazoles and pyrimidines as topo-II inhibitors and DNA intercalators.

Design, nanogel synthesis, anti-proliferative activity and <i>in silico</i> ADMET profile of pyrazoles and pyrimidines as topo-II inhibitors and DNA intercalators.

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第一作者： Ahmed K B,Aljohani

第一单位： Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University Medina 42353 Saudi Arabia.

作者： Ahmed K B,Aljohani ^[1] ; Sanadelaslam S A,El-Hddad ^[2] ; Marwa,Alsulaimany ^[1] ; Nader A,Maghrabi ^[3] ; Alaa M,Alhammad ^[3] ; Mayar N,Aloufi ^[3] ; Luai F,Alahmadi ^[3] ; Turkiah,Ali Saeedi ^[3] ; Yousef Yakoub,Neyaz ^[3] ; Kurls E,Anwer ^[4] ; Nour E A,Abd El-Sattar ^[5] ; Khaled,El-Adl ^[6]

作者单位： Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University Medina 42353 Saudi Arabia. ^[1] Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University Al Bayda 991 Libya. ^[2] Pharmacy Student, College of Pharmacy, Taibah University Medina Saudi Arabia. ^[3] Department of Chemistry, Faculty of Science, Ain Shams University Abbassia Cairo Egypt. ^[4] Department of Chemistry, Faculty of Science, Ain Shams University Abbassia Cairo Egypt.;Basic & Medical Sciences Department, Faculty of Dentistry, Alryada University for Science & Technology Egypt. ^[5] Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development Cairo Egypt eladlkhaled74@yahoo.com khaled.eladl@hu.edu.eg.;Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Nasr City 11884 Cairo Egypt eladlkhaled74@azhar.edu.eg. ^[6]

DOI 10.1039/d5ra00166h

PMID 40171282

发布时间 2025-04-02

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