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SpaGRN: Investigating spatially informed regulatory paths for spatially resolved transcriptomics data.

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第一作者： Yao,Li

第一单位： BGI Research, Sanya 572025, China; BGI Research, Qingdao 266555, China.

作者： Yao,Li ^[1] ; Xiaobin,Liu ^[2] ; Lidong,Guo ^[3] ; Kai,Han ^[2] ; Shuangsang,Fang ^[4] ; Xinjiang,Wan ^[5] ; Dantong,Wang ^[2] ; Xun,Xu ^[6] ; Ling,Jiang ^[7] ; Guangyi,Fan ^[8] ; Mengyang,Xu ^[9]

作者单位： BGI Research, Sanya 572025, China; BGI Research, Qingdao 266555, China. ^[1] BGI Research, Qingdao 266555, China. ^[2] BGI Research, Qingdao 266555, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China. ^[3] BGI Research, Beijing 102601, China; BGI Research, Shenzhen 518083, China. ^[4] CAS Key Laboratory of Marine Ecology and Environmental Sciences, and Center of Deep Sea Research Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. ^[5] BGI Research, Wuhan 430074, China; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China. ^[6] State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China. Electronic address: jiangling@njtech.edu.cn. ^[7] BGI Research, Sanya 572025, China; BGI Research, Qingdao 266555, China; BGI Research, Shenzhen 518083, China; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China. Electronic address: fanguangyi@genomics.cn. ^[8] BGI Research, Sanya 572025, China; BGI Research, Qingdao 266555, China; BGI Research, Shenzhen 518083, China; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China. Electronic address: xumengyang@genomics.cn. ^[9]

关键词 3D regulatory atlas cellular interaction mapping gene regulatory network receptor receptor-TF-target cascades spatial autocorrelation analysis spatially resolved transcriptomics spatiotemporal dynamics transcription factor

医学主题词动物(Animals);基因表达谱(Gene Expression Profiling);人类(Humans);基因调控网络(Gene Regulatory Networks);果蝇属(Drosophila);计算生物学(Computational Biology)

DOI 10.1016/j.cels.2025.101243

PMID 40179878

发布时间 2025-04-18

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