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PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.

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第一作者： Bhargab,Kalita

第一单位： Department of Pathology and Perlmutter Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: bhargab.kalita@nyulangone.org.

作者： Bhargab,Kalita ^[1] ; Gerard,Martinez-Cebrian ^[2] ; Justina,McEvoy ^[3] ; Melody,Allensworth ^[3] ; Michelle,Knight ^[4] ; Alessandro,Magli ^[5] ; Rita C R,Perlingeiro ^[6] ; Michael A,Dyer ^[3] ; Elizabeth,Stewart ^[7] ; Brian David,Dynlacht ^[8]

作者单位： Department of Pathology and Perlmutter Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: bhargab.kalita@nyulangone.org. ^[1] Department of Pathology and Perlmutter Cancer Institute, New York University School of Medicine, New York, NY 10016, USA; Josep Carreras Leukaemia Research Institute, 08916 Badalona, Spain. ^[2] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105, USA. ^[3] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105, USA; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[4] Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Genomic Medicine Unit, Sanofi, 225nd Avenue, Waltham, MA 02451, USA. ^[5] Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA. ^[6] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105, USA; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: elizabeth.stewart@stjude.org. ^[7] Department of Pathology and Perlmutter Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: brian.dynlacht@nyulangone.org. ^[8]

关键词 3D/2D-adapted PDX models Leucine MYCN TRMT5 alveolar rhabdomyosarcoma mitochondrial metabolism myogenic progenitors roblitinib tRNA modifications tigecycline