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Deep-learning-assisted medium optimization improves hyaluronic acid production by Streptococcus zooepidemicus.

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第一作者： Kazuki,Watanabe

第一单位： Department of Biotechnology and Environmental Chemistry, Graduate School of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan.

作者： Kazuki,Watanabe ^[1] ; Yoshizumi,Kawai ^[2] ; Tomoko,Kagenishi ^[2] ; Tai-Ying,Chiou ^[2] ; Masaaki,Konishi ^[3]

作者单位： Department of Biotechnology and Environmental Chemistry, Graduate School of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan. ^[1] Biotechnology and Food Chemistry Course Program, School of Regional Innovation and Social Design Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan. ^[2] Biotechnology and Food Chemistry Course Program, School of Regional Innovation and Social Design Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan. Electronic address: konishim@mail.kitami-it.ac.jp. ^[3]

关键词 Artificial intelligence Bayesian optimization Deep neural network Design of experiment Genetic algorithm Hyaluronic acid Streptococcus zooepidemicus

医学主题词透明质酸(Hyaluronic Acid);马链球菌(Streptococcus equi);培养基(Culture Media);生物反应器(Bioreactors);算法(Algorithms)

DOI 10.1016/j.jbiosc.2025.03.001

PMID 40189954

发布时间 2025-05-18

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