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Large-scale discovery, analysis, and design of protein energy landscapes.

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第一作者： Állan J R,Ferrari

第一单位： Department of Pharmacology & Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

作者： Állan J R,Ferrari ^[1] ; Sugyan M,Dixit ^[1] ; Jane,Thibeault ^[1] ; Mario,Garcia ^[1] ; Scott,Houliston ^[2] ; Robert W,Ludwig ^[1] ; Pascal,Notin ^[3] ; Claire M,Phoumyvong ^[1] ; Cydney M,Martell ^[1] ; Michelle D,Jung ^[1] ; Kotaro,Tsuboyama ^[4] ; Lauren,Carter ^[5] ; Cheryl H,Arrowsmith ^[2] ; Miklos,Guttman ^[6] ; Gabriel J,Rocklin ^[7]

作者单位： Department of Pharmacology & Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ^[1] Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada. ^[2] Department of Systems Biology, Harvard Medical School, Boston, MA, USA. ^[3] Department of Pharmacology & Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Current address: Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. ^[4] Department of Biochemistry, University of Washington, Seattle, WA, USA. Current address: Bill & Melinda Gates Medical Research Institute. ^[5] Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA. ^[6] Department of Pharmacology & Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ^[7]

DOI 10.1101/2025.03.20.644235

PMID 40196533

发布时间 2026-05-19

基金项目

DP2 GM140927/GM/NIGMS NIH HHS/United States F31 GM151811/GM/NIGMS NIH HHS/United States T32 GM008382/GM/NIGMS NIH HHS/United States T32 GM149439/GM/NIGMS NIH HHS/United States

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