Autologous T cell therapy for PRAME<sup>+</sup> advanced solid tumors in HLA-A*02<sup>+</sup> patients: a phase 1 trial.
第一作者:
Martin,Wermke
第一单位:
Department of Medicine I, University Hospital Carl Gustav Carus TU Dresden, Dresden, Germany.;National Center for Tumor Diseases, Dresden, Germany.
作者:
医学主题词
人类(Humans);男(雄)性(Male);中年人(Middle Aged);女(雌)性(Female);抗原, 肿瘤(Antigens, Neoplasm);T淋巴细胞(T-Lymphocytes);老年人(Aged);成年人(Adult);HLA-A2抗原(HLA-A2 Antigen);黑色素瘤(Melanoma);肿瘤(Neoplasms);免疫疗法, 过继(Immunotherapy, Adoptive);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);最大耐受剂量(Maximum Tolerated Dose);肉瘤(Sarcoma);移植, 自体(Transplantation, Autologous)
DOI
10.1038/s41591-025-03650-6
PMID
40205198
发布时间
2025-08-30
基金项目
UM1 TR004906/TR/NCATS NIH HHS/United States
DP150029/Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas)
L30 CA123720/CA/NCI NIH HHS/United States
R01 CA306089/CA/NCI NIH HHS/United States
M01 RR000847/RR/NCRR NIH HHS/United States
- 浏览2
Nature medicine
2365-2374页
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