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Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

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第一作者： A R,Koskenniemi

第一单位： Department of Pathology, Laboratory Division, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address: anna-riina.koskenniemi@varha.fi.

作者： A R,Koskenniemi ^[1] ; T,Huusko ^[2] ; J,Routila ^[3] ; S,Jalkanen ^[4] ; M,Hollmén ^[4] ; P,Vainio ^[5] ; S,Ventelä ^[6]

作者单位： Department of Pathology, Laboratory Division, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address: anna-riina.koskenniemi@varha.fi. ^[1] Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland. ^[2] Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. ^[3] MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland. ^[4] Department of Pathology, Laboratory Division, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. ^[5] Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20521 Turku, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; FICAN West Cancer Centre, Turku, Finland. ^[6]

关键词 Chemoradiotherapy HNSCC Immune landscape Neoadjuvant therapy Radiotherapy Tumor necrosis