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AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma.

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第一作者: Jiaming,Yu
第一单位: Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.;Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
作者: Jiaming,Yu [1] ; Chuanxia,Zhang [1] ; Qinkai,Zhang [2] ; Bing,Lu [1] ; Guohao,Lu [3] ; Chunxiao,Zhang [4] ; Ru,Qiu [5] ; Xinyue,Wang [5] ; Changye,Zou [6] ; Junjun,Chu [7] ; Haizhou,Li [8] ; Wei,Zhao [9]
作者单位: Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.;Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. [1] Department of Breast and Thyroid Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China. [2] Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510000, China. [3] School of Laboratory Medicine, Guangzhou Health Science College, Guangzhou, 510450, China. [4] Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510000, China.;Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510000, China. [5] Musculoskeletal Oncology Center, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. [6] HRYZ Biotech Co., Guangzhou, 510507, China. chujunjun@gmail.com. [7] Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, 341000, China. seany1253@163.com. [8] Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. zhaowei23@mail.sysu.edu.cn.;Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. zhaowei23@mail.sysu.edu.cn.;Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, 510000, China. zhaowei23@mail.sysu.edu.cn.;Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510000, China. zhaowei23@mail.sysu.edu.cn. [9]
DOI 10.1038/s41419-025-07640-x
PMID 40246846
发布时间 2025-04-20
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