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G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor.

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第一作者： Xin,Li

第一单位： Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.

作者： Xin,Li ^[1] ; Maria,Rossing ^[2] ; Ana,Moisés da Silva ^[3] ; Muthiah,Bose ^[4] ; Thorkell,Gudjónsson ^[1] ; Jan,Benada ^[1] ; Jayashree,Thatte ^[1] ; Jens Vilstrup,Johansen ^[1] ; Judit,Börcsök ^[5] ; Hanneke,van der Gulden ^[3] ; Ji-Ying,Song ^[6] ; Renée,Menezes ^[7] ; Asma,Tajik ^[1] ; Lucía,Sena ^[1] ; Zoltan,Szallasi ^[8] ; Morten,Frödin ^[1] ; Jos,Jonkers ^[3] ; Finn Cilius,Nielsen ^[9] ; Claus Storgaard,Sørensen ^[1]

作者单位： Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. ^[1] Center for Genomic Medicine, Rigshospitalet, and.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. ^[2] Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, Netherlands.;Oncode Institute, Utrecht, Netherlands. ^[3] Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.;Center for Genomic Medicine, Rigshospitalet, and. ^[4] Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.;Translational Cancer Genomics Group, Danish Cancer Institute, Copenhagen, Denmark. ^[5] Oncode Institute, Utrecht, Netherlands. ^[6] Biostatistics Centre & Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, Netherlands. ^[7] Translational Cancer Genomics Group, Danish Cancer Institute, Copenhagen, Denmark.;Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.;Department of Bioinformatics, Semmelweis University, Budapest, Hungary. ^[8] Center for Genomic Medicine, Rigshospitalet, and. ^[9]

关键词 Breast cancer Cell biology Clinical Research DNA repair Genetic instability Genetics

医学主题词女(雌)性(Female);人类(Humans);动物(Animals);小鼠(Mice);乳腺肿瘤(Breast Neoplasms);DNA断裂, 双链(DNA Breaks, Double-Stranded);BRCA1蛋白质(BRCA1 Protein);生殖细胞系突变(Germ-Line Mutation);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);基因组不稳定性(Genomic Instability)

DOI 10.1172/jci.insight.186747

PMID 40261702

发布时间 2026-07-22

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G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor.

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