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The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer.

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第一作者： Valentina,Cutano

第一单位： Bioscience, Early Oncology, AstraZeneca, Cambridge, UK.

作者： Valentina,Cutano ^[1] ; Ming Li,Chia ^[2] ; Eleanor M,Wigmore ^[3] ; Lorna,Hopcroft ^[1] ; Stuart C,Williamson ^[1] ; Amanda L,Christie ^[4] ; Brandon,Willis ^[4] ; James,Kerr ^[1] ; Jenny,Ashforth ^[1] ; Rhys,Fox ^[1] ; Sophie,D'Arcy ^[1] ; Lauren,Bradshaw ^[1] ; Catherine,Blaker ^[1] ; Cath,Eberlein ^[1] ; Lambert,Montava-Garriga ^[5] ; Elza C,de Bruin ^[6] ; Susan E,Critchlow ^[1] ; Kevin M,Brindle ^[2] ; Simon T,Barry ^[1] ; Susana,Ros ^[7]

作者单位： Bioscience, Early Oncology, AstraZeneca, Cambridge, UK. ^[1] Cancer Research UK Cambridge Institute, Cambridge, UK. ^[2] Early Data Science, Oncology Data Science, AstraZeneca, Cambridge, UK. ^[3] Bioscience, Early Oncology, AstraZeneca, Boston, MA, USA. ^[4] Discovery Sciences, AstraZeneca, Cambridge, UK. ^[5] Translational Medicine, AstraZeneca, Cambridge, UK. ^[6] Bioscience, Early Oncology, AstraZeneca, Cambridge, UK. susana.ros@astrazeneca.com. ^[7]

DOI 10.1038/s41523-025-00752-9

PMID 40263319

发布时间 2025-04-24

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NPJ breast cancer

2025年11卷1期

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NPJ breast cancer

2025年11卷1期

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The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer.

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The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer.

NPJ breast cancer

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NPJ breast cancer

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