换一批
第一作者：
Marcos,Díaz-Gay
第一单位：
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.;Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.;Digital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
作者：
Marcos,Díaz-Gay [1]
;
Wellington,Dos Santos [2]
;
Sarah,Moody [3]
;
Mariya,Kazachkova [4]
;
Ammal,Abbasi [5]
;
Christopher D,Steele [5]
;
Raviteja,Vangara [5]
;
Sergey,Senkin [2]
;
Jingwei,Wang [3]
;
Stephen,Fitzgerald [3]
;
Erik N,Bergstrom [5]
;
Azhar,Khandekar [6]
;
Burçak,Otlu [7]
;
Behnoush,Abedi-Ardekani [2]
;
Ana Carolina,de Carvalho [2]
;
Thomas,Cattiaux [2]
;
Ricardo Cortez Cardoso,Penha [2]
;
Valérie,Gaborieau [2]
;
Priscilia,Chopard [2]
;
Christine,Carreira [8]
;
Saamin,Cheema [3]
;
Calli,Latimer [3]
;
Jon W,Teague [3]
;
Anush,Mukeriya [9]
;
David,Zaridze [9]
;
Riley,Cox [10]
;
Monique,Albert [11]
;
Larry,Phouthavongsy [10]
;
Steven,Gallinger [12]
;
Reza,Malekzadeh [13]
;
Ahmadreza,Niavarani [13]
;
Marko,Miladinov [14]
;
Katarina,Erić [15]
;
Sasa,Milosavljevic [16]
;
Suleeporn,Sangrajrang [17]
;
Maria Paula,Curado [18]
;
Samuel,Aguiar [19]
;
Rui Manuel,Reis [20]
;
Monise Tadin,Reis [21]
;
Luis Gustavo,Romagnolo [22]
;
Denise Peixoto,Guimarães [23]
;
Ivana,Holcatova [24]
;
Jaroslav,Kalvach [25]
;
Carlos Alberto,Vaccaro [26]
;
Tamara Alejandra,Piñero [26]
;
Beata,Świątkowska [27]
;
Jolanta,Lissowska [28]
;
Katarzyna,Roszkowska-Purska [29]
;
Antonio,Huertas-Salgado [30]
;
Tatsuhiro,Shibata [31]
;
Satoshi,Shiba [32]
;
Surasak,Sangkhathat [33]
;
Taned,Chitapanarux [34]
;
Gholamreza,Roshandel [35]
;
Patricia,Ashton-Prolla [36]
;
Daniel C,Damin [37]
;
Francine Hehn,de Oliveira [38]
;
Laura,Humphreys [3]
;
Trevor D,Lawley [39]
;
Sandra,Perdomo [2]
;
Michael R,Stratton [3]
;
Paul,Brennan [2]
;
Ludmil B,Alexandrov [40]
作者单位：
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.;Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.;Digital Genomics Group, Structural Biology Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
[1]
Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
[2]
Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
[3]
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.;Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
[4]
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.;Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
[5]
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.;Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.;Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
[6]
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.;Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.;Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.
[7]
Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
[8]
Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
[9]
Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
[10]
Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.;Centre for Biodiversity Genomics, University of Guelph, Guelph, Ontario, Canada.
[11]
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
[12]
Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
[13]
Clinic for Digestive Surgery-First Surgical Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.
[14]
Department of Pathology, University Clinical Centre of Serbia, Belgrade, Serbia.
[15]
International Organization for Cancer Prevention and Research, Belgrade, Serbia.
[16]
National Cancer Institute, Bangkok, Thailand.
[17]
Department of Epidemiology, A. C. Camargo Cancer Center, Sao Paulo, Brazil.
[18]
Colon Cancer Reference Center, A. C. Camargo Cancer Center, Sao Paulo, Brazil.
[19]
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.;Life and Health Sciences Research Institute (ICVS), School of Medicine, Minho University, Braga, Portugal.
[20]
Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil.
[21]
Department of Colorectal Oncology Surgery, Barretos Cancer Hospital, Barretos, Brazil.
[22]
Department of Endoscopy, Barretos Cancer Hospital, Barretos, Brazil.
[23]
Department of Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.;Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
[24]
Surgery Department, 2nd Faculty of Medicine, Charles University and Central Military Hospital, Prague, Czech Republic.;2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.;Institute of Animal Physiology and Genetics Czech Academy of Science, Libechov, Czech Republic.;Clinical Center ISCARE, Prague, Czech Republic.
[25]
Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina.
[26]
Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
[27]
The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland.
[28]
Department of Pathology, The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland.
[29]
Oncological Pathology Group, Terry Fox National Tumor Bank (Banco Nacional de Tumores Terry Fox), National Cancer Institute, Bogotá, Colombia.
[30]
Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.;Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan.
[31]
Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan.
[32]
Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.;Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.;Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
[33]
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
[34]
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
[35]
Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.;Medical Genetics Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
[36]
Department of Surgery, Division of Colorectal Surgery, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
[37]
Department of Pathology, Anatomic Pathology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
[38]
Parasites and Microbes, Wellcome Sanger Institute, Cambridge, UK.
[39]
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.;Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.;Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.;Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.
[40]
医学主题词
结直肠肿瘤(Colorectal Neoplasms);人类(Humans);中年人(Middle Aged);老年人(Aged);成年人(Adult);突变(Mutation);肽类(Peptides);女(雌)性(Female);男(雄)性(Male);微卫星不稳定性(Microsatellite Instability);发病率(Incidence);发病年龄(Age of Onset);年龄因素(Age Factors);诱变剂(Mutagens);哥伦比亚(Colombia);巴西(Brazil);泰国(Thailand);INDEL突变(INDEL Mutation);阿根廷(Argentina);俄罗斯(Russia)
DOI
10.1038/s41586-025-09025-8
PMID
40267983
发布时间
2025-07-04
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Nature
Nature
230-240页
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