首页> Comprehensive Physiology> Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype.

Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype.

导出 OA

翻译打印收藏纠错

第一作者： Charles C T,Hindmarch

第一单位： Department of Biomedical and Molecular Science (DBMS), Queen's University, Kingston, Ontario, Canada.;Department of Medicine, Queen's University, Kingston, Ontario, Canada.;Queen's CardioPulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Kingston, Ontario, Canada.

作者： Charles C T,Hindmarch ^[1] ; François,Potus ^[2] ; Ruaa,Al-Qazazi ^[3] ; Benjamin P,Ott ^[4] ; William C,Nichols ^[5] ; Michael J,Rauh ^[6] ; Stephen L,Archer ^[4]

作者单位： Department of Biomedical and Molecular Science (DBMS), Queen's University, Kingston, Ontario, Canada.;Department of Medicine, Queen's University, Kingston, Ontario, Canada.;Queen's CardioPulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Kingston, Ontario, Canada. ^[1] Pulmonary Hypertension Research Group, Center de Recherche de L'institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. ^[2] Department of Medicine, Queen's University, Kingston, Ontario, Canada. ^[3] Department of Medicine, Queen's University, Kingston, Ontario, Canada.;Queen's CardioPulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Kingston, Ontario, Canada. ^[4] Division of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. ^[5] Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. ^[6]

关键词 DNA methylation T cell differentiation epigenetic metabolism reduced representation bisulfite sequencing (RRBS)transcription factor 7 (TCF7)