换一批IL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue.
第一作者：
Kim M,Kaiser
第一单位：
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
作者：
Kim M,Kaiser [1]
;
Jan,Raabe [1]
;
Michael,ToVinh [1]
;
Gudrun,Hack [1]
;
Sarah,Ahmad [1]
;
Niko,Müller [1]
;
Julia,Cassella [1]
;
Sofia I,Walravens [1]
;
Paula,Alfaro [1]
;
Lauren,Arias Garcia [1]
;
Dominik J,Kaczmarek [2]
;
Tim,Marwitz [2]
;
Felix,Goeser [1]
;
Hans Dieter,Nischalke [1]
;
Philipp,Lutz [1]
;
Nils,Sommer [3]
;
Tim,Vilz [4]
;
Marieta,Toma [5]
;
Susanne,Steiner [5]
;
Oliver,Hommerding [6]
;
Johannes,Oldenburg [7]
;
Michael,Hölzel [8]
;
Sebastian,Kadzik [8]
;
Alexander,Maas [9]
;
Jonas,Eckrich [10]
;
Philipp,Zumfelde [11]
;
Farhad,Shakeri [12]
;
Svetozar,Nesic [12]
;
Andreas,Buness [13]
;
Emilia,De Caro [14]
;
Matthias,Becker [15]
;
Marc D,Beyer [16]
;
Thomas,Ulas [17]
;
Anna C,Aschenbrenner [15]
;
Lisa M,Steinheuer [8]
;
Kevin,Thurley [18]
;
Sandy,Kroh [19]
;
Ralf,Uecker [20]
;
Anja E,Hauser [20]
;
Florian N,Gohr [21]
;
Florian I,Schmidt [21]
;
Danni,Wang [22]
;
Kathrin,Held [23]
;
Olga,Baranov [22]
;
Christof,Geldmacher [23]
;
Christian P,Strassburg [2]
;
Robert,Hüneburg [2]
;
Benjamin,Krämer [24]
;
Jacob,Nattermann [25]
作者单位：
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
[1]
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.;National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.
[2]
Department of Surgery, University Hospital Bonn, Bonn, Germany.
[3]
National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.;Department of Surgery, University Hospital Bonn, Bonn, Germany.
[4]
Department of Pathology, University Hospital Bonn, Bonn, Germany.
[5]
National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.;Department of Pathology, University Hospital Bonn, Bonn, Germany.
[6]
Institute of Experimental Haematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany.
[7]
Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.
[8]
Department of Otorhinolaryngology, University Hospital Bonn, Bonn, Germany.
[9]
Department for Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mainz, Mainz, Germany.
[10]
Gastroenterology, Bonn, Germany.
[11]
Institute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
[12]
Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
[13]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.;Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
[14]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
[15]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.;Immunogenomics & Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.;PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE, University of Bonn, and West German Genome Center, Bonn, Germany.
[16]
Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.;Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.;PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE, University of Bonn, and West German Genome Center, Bonn, Germany.
[17]
Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.;Systems Biology of Inflammation, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.
[18]
Systems Biology of Inflammation, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, Germany.;Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Berlin, Germany.
[19]
Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Berlin, Germany.;Immune Dynamics, Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, 10117, Berlin, Germany.
[20]
Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
[21]
Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.
[22]
Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 81377, Munich, Germany.;German Center for Infection Research (DZIF), Bonn, Germany.
[23]
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany. benjamin.kraemer@ukbonn.de.
[24]
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany. jacob.nattermann@ukbonn.de.;National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany. jacob.nattermann@ukbonn.de.;German Center for Infection Research (DZIF), Bonn, Germany. jacob.nattermann@ukbonn.de.
[25]
医学主题词
白细胞介素17(Interleukin-17);人类(Humans);结肠腺瘤息肉病(Adenomatous Polyposis Coli);淋巴细胞(Lymphocytes);活性氧(Reactive Oxygen Species);十二指肠(Duodenum);免疫, 先天(Immunity, Innate);男(雄)性(Male);白细胞介素23亚单位p19(Interleukin-23 Subunit p19);女(雌)性(Female);白细胞介素1β(Interleukin-1beta);十二指肠肿瘤(Duodenal Neoplasms);类器官(Organoids);膜蛋白质类(Membrane Proteins);DNA损伤(DNA Damage)
DOI
10.1038/s41467-025-58907-y
PMID
40280932
发布时间
2025-04-28
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