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Comparative Forced Degradation Study of Anticomplement C5 Biosimilar and Originator Monoclonal Antibodies.

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第一作者： Merve,Celik Yamaci

第一单位： Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34638 Istanbul, Türkiye.;Biotechnology Group, Turgut Ilaclari A.S., 41400 Kocaeli, Türkiye.

作者： Merve,Celik Yamaci ^[1] ; Ceren,Pamukcu ^[2] ; Yigit,Erdemgil ^[2] ; Ahmet Emin,Atik ^[3] ; Zeynep Zulfiye Yildirim,Keles ^[2] ; Ozge,Can ^[4]

作者单位： Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34638 Istanbul, Türkiye.;Biotechnology Group, Turgut Ilaclari A.S., 41400 Kocaeli, Türkiye. ^[1] Biotechnology Group, Turgut Ilaclari A.S., 41400 Kocaeli, Türkiye. ^[2] Biotechnology Group, Turgut Ilaclari A.S., 41400 Kocaeli, Türkiye.;Department of Natural Sciences, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, 34638 Istanbul, Türkiye. ^[3] Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, 34638 Istanbul, Türkiye. ^[4]

关键词 biological activity biosimilar mAb capillary electrophoresis forced degradation isoelectric focusing monoclonal antibody size exclusion chromatography

DOI 10.3390/ph18040579

PMID 40284014

发布时间 2025-04-28

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