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iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.

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第一作者： Hangping,Fan

第一单位： Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China.

作者： Hangping,Fan ^[1] ; Zongkuai,Yang ^[1] ; Hangying,Ying ^[2] ; Jiuxiao,Zhao ^[3] ; Xiaochen,Wang ^[1] ; Junhao,Gong ^[4] ; Lingying,Li ^[4] ; Xujie,Liu ^[4] ; Tingyu,Gong ^[5] ; Qing,Ke ^[6] ; Lenan,Zhuang ^[7] ; Ping,Liang ^[8]

作者单位： Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China. ^[1] Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China. ^[2] Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China. ^[3] Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, 518052, China. ^[4] Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310015, China. Electronic address: 11918392@zju.edu.cn. ^[5] Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. Electronic address: keqing2003@zju.edu.cn. ^[6] Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: zhuangln@zju.edu.cn. ^[7] Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China. Electronic address: pingliang@zju.edu.cn. ^[8]

关键词 EDMD EHTs JAK2/STAT3 signaling ROS iPSC-CMs lamin A/C

医学主题词 STAT3转录因子(STAT3 Transcription Factor);诱导多能干细胞(Induced Pluripotent Stem Cells);肌细胞, 心脏(Myocytes, Cardiac);人类(Humans);核纤层蛋白A型(Lamin Type A);信号传导(Signal Transduction);肌营养不良, Emery-Dreifuss型(Muscular Dystrophy, Emery-Dreifuss);Janus激酶2(Janus Kinase 2);突变(Mutation);组织工程(Tissue Engineering)

DOI 10.1016/j.redox.2025.103638

PMID 40286437

发布时间 2025-05-18

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iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.

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iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy.

Redox biology

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