首页> Journal of pharmaceutical and biomedical analysis> Automated derivatization with 6-aminoquinolyl-N-hydroxysccinimidyl carbamate for the enantioselective amino acid analysis of neurotensin synthesized by liquid phase peptide synthesis.

Automated derivatization with 6-aminoquinolyl-N-hydroxysccinimidyl carbamate for the enantioselective amino acid analysis of neurotensin synthesized by liquid phase peptide synthesis.

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第一作者： Ryan,Karongo

第一单位： Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany; Invite GmbH, Formulation Technology, Köln 51061, Germany; Bayer AG, Wuppertal 42096, Germany. Electronic address: ryan.karongo@bayer.com.

作者： Ryan,Karongo ^[1] ; Feiyang,Li ^[2] ; Franz,Fiessinger ^[2] ; Adrian,Sievers-Engler ^[2] ; Isabell,Kroth ^[3] ; Sarah,Resch ^[3] ; Lars,Baumann ^[3] ; Alexander,Novak ^[3] ; Mimi,Gao ^[3] ; Terence,Hetzel ^[3] ; Wiebke,Holkenjans ^[3] ; Werner,Hoheisel ^[3] ; Reinhard,Pell ^[3] ; Michael,Gottfried ^[3] ; Michael,Lämmerhofer ^[4]

作者单位： Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany; Invite GmbH, Formulation Technology, Köln 51061, Germany; Bayer AG, Wuppertal 42096, Germany. Electronic address: ryan.karongo@bayer.com. ^[1] Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany. ^[2] Bayer AG, Wuppertal 42096, Germany. ^[3] Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany. Electronic address: michael.laemmerhofer@uni-tuebingen.de. ^[4]

关键词 Amino acid Automation Impurity Precolummn derivatization Racemization Therapeutic peptides