首页> mBio> An antisense oligomer conjugate with unpredicted bactericidal activity against <i>Fusobacterium nucleatum</i>.

An antisense oligomer conjugate with unpredicted bactericidal activity against <i>Fusobacterium nucleatum</i>.

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第一作者： Valentina,Cosi

第一单位： Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.

作者： Valentina,Cosi ^[1] ; Jakob,Jung ^[1] ; Linda,Popella ^[2] ; Falk,Ponath ^[1] ; Chandradhish,Ghosh ^[1] ; Lars,Barquist ^[3] ; Jörg,Vogel ^[4]

作者单位： Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. ^[1] RNA Biology Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg RNA Biology Group, Würzburg, Germany.;Cluster for Nucleic Acid Therapeutics Munich (CNATM), Munich, Germany. ^[2] Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.;Department of Biology, University of Toronto, Mississauga, Ontario, Canada. ^[3] Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.;RNA Biology Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg RNA Biology Group, Würzburg, Germany.;Cluster for Nucleic Acid Therapeutics Munich (CNATM), Munich, Germany. ^[4]

关键词 Fusobacterium nucleatum antisense antibiotic cell-penetrating peptide envelope stress morpholino peptide nucleic acid

医学主题词具核梭杆菌(Fusobacterium nucleatum);抗菌药(Anti-Bacterial Agents);细胞穿透性肽类(Cell-Penetrating Peptides);肽核酸类(Peptide Nucleic Acids);人类(Humans);微生物敏感性试验(Microbial Sensitivity Tests)

DOI 10.1128/mbio.00524-25

PMID 40298409

发布时间 2025-06-13

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