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The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma.

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第一作者： Tommaso,Perini

第一单位： Age Related Diseases Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy.;Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy.

作者： Tommaso,Perini ^[1] ; Paola,Zordan ^[2] ; Rossella,Del Pizzo ^[3] ; Massimo,Resnati ^[3] ; Lisa,Viviani ^[3] ; Davide,Stefanoni ^[4] ; Laura,Cassina ^[4] ; Ugo,Orfanelli ^[3] ; Matteo,Trudu ^[3] ; Laura,Oliva ^[3] ; Daniel,Lacidogna ^[3] ; Mehmet K,Samur ^[5] ; Maria,Materozzi ^[3] ; Denise,Drago ^[6] ; Annapaola,Andolfo ^[6] ; Marco,Patrone ^[7] ; Massimo,Degano ^[8] ; Alessandra,Boletta ^[4] ; Enrico,Milan ^[9] ; Fabio,Ciceri ^[10] ; Nikhil C,Munshi ^[11] ; Matteo,Bellone ^[2] ; Simone,Cenci ^[9]

作者单位： Age Related Diseases Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy.;Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy. ^[1] Cellular Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy. ^[2] Age Related Diseases Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy. ^[3] Cystic Kidney Disorders Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy. ^[4] Department of Data Science, Dana-Farber Cancer Institute, Boston, MA.;Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA. ^[5] Proteomics and Metabolomics Facility, Center for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy. ^[6] Biocrystallography Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy. ^[7] Biocrystallography Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.;Vita-Salute San Raffaele University, Milan, Italy. ^[8] Age Related Diseases Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy.;Vita-Salute San Raffaele University, Milan, Italy. ^[9] Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy.;Vita-Salute San Raffaele University, Milan, Italy. ^[10] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. ^[11]