首页> Drug metabolism and disposition: the biological fate of chemicals> Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier.

Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier.

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第一作者： Hao,Zhi

第一单位： Center of Drug Metabolism and Pharmacokinetics, Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.

作者： Hao,Zhi ^[1] ; Zhongyan,Wang ^[1] ; Xinyue,Zhu ^[1] ; Wenhan,Wu ^[1] ; Lu,Yang ^[1] ; Yidong,Dai ^[1] ; Zehua,Wang ^[1] ; Ling,Jiang ^[1] ; Yongmei,Tan ^[1] ; Xiaodong,Liu ^[2] ; Li,Liu ^[3]

作者单位： Center of Drug Metabolism and Pharmacokinetics, Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. ^[1] Center of Drug Metabolism and Pharmacokinetics, Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. Electronic address: xdliu@cpu.edu.cn. ^[2] Center of Drug Metabolism and Pharmacokinetics, Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China. Electronic address: liulee@cpu.edu.cn. ^[3]

关键词 Blood-brain barrier Chenodeoxycholic acid Estradiol Hepatic encephalopathy Organic cation transporters