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Role of membrane proximal actin regulators in SARS-CoV-2 spike-induced cell-cell fusion.

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第一作者： Linting,Kou

第一单位： Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan.

作者： Linting,Kou ^[1] ; Yumeng,Wan ^[1] ; Yuri L,Nemoto ^[2] ; Kazuya,Tsujita ^[3] ; Toshiki,Itoh ^[4]

作者单位： Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan. ^[1] Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan; Biosignal Research Center, Kobe University, Kobe, Hyogo, 657-8501, Japan. ^[2] Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan; Biosignal Research Center, Kobe University, Kobe, Hyogo, 657-8501, Japan. Electronic address: tsujita@people.kobe-u.ac.jp. ^[3] Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan; Biosignal Research Center, Kobe University, Kobe, Hyogo, 657-8501, Japan. Electronic address: titoh@people.kobe-u.ac.jp. ^[4]

关键词 Actin cytoskeleton BAR proteins Cell-cell fusion SARS-CoV-2 Syncytia formation

医学主题词人类(Humans);细胞融合(Cell Fusion);肌动蛋白类(Actins);细胞膜(Cell Membrane);巨细胞(Giant Cells);动物(Animals);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)

DOI 10.1016/j.bbrc.2025.151846

PMID 40300332

发布时间 2025-05-11

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