POU6F2 promotes liver metastasis of gastric adenocarcinoma by dual mechanism of transcriptional upregulation of SNAI1 and IGF2/PI3K/AKT signaling-induced conversion of hepatic stellate cells into cancer-associated fibroblasts.-论文-万方医学网

第一作者： Chunxiao,Yang

第一单位： The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, China.;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Guangzhou Medical University, Guangzhou, China.

作者： Chunxiao,Yang ^[1] ; Zhiqing,Gao ^[2] ; Ruiming,Tang ^[3] ; Lihuan,Zhou ^[3] ; Ping,Zhou ^[4] ; Wangpan,Shi ^[5] ; Dong,Ren ^[6] ; Han,Chen ^[1] ; Zhuojun,Zhang ^[1] ; Xiaoyi,Xie ^[1] ; Jiaqian,Lin ^[1] ; Yingming,Ye ^[7] ; Zhengfu,Feng ^[3] ; Xiaoli,Feng ^[3] ; Yaoming,He ^[8] ; Yaofeng,Zhi ^[9] ; Dongmei,Liu ^[9] ; Xin,Zhang ^[10] ; Lili,Jiang ^[11]

作者单位： The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, China.;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Guangzhou Medical University, Guangzhou, China. ^[1] Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Guangzhou Medical University, Guangzhou, China.;Department of Molecular Medicine, School of Basic Medicine, Southern Medical University, Guangzhou, China. ^[2] The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, China. ^[3] Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Guangzhou Medical University, Guangzhou, China. ^[4] Department of Pathology, University of California San Diego Health System, San Diego, CA, USA. ^[5] Departments of Pathology, University of California Irvine Medical Center, Orange, CA, USA. ^[6] Department of Pathogen Biology and Immunology, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, China. ^[7] Department of Gastrointestinal Surgery, Jiangmen Central Hospital, Jiangmen, China. ^[8] Clinical Experimental Center, Jiangmen Key Laboratory of Precision and Clinical Translation Medicine, Jiangmen Clinical Medical College of Guangdong Medical University, Jiangmen Central Hospital, Jiangmen, China. ^[9] Clinical Experimental Center, Jiangmen Key Laboratory of Precision and Clinical Translation Medicine, Jiangmen Clinical Medical College of Guangdong Medical University, Jiangmen Central Hospital, Jiangmen, China. zhangx45@mail3.sysu.edu.cn. ^[10] The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, China. jianglili@gzhmu.edu.cn.;Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Guangzhou Medical University, Guangzhou, China. jianglili@gzhmu.edu.cn. ^[11]

医学主题词人类(Humans);动物(Animals);肝肿瘤(Liver Neoplasms);胃肿瘤(Stomach Neoplasms);小鼠(Mice);肝星状细胞(Hepatic Stellate Cells);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);信号传导(Signal Transduction);增量调节(Up-Regulation);腺癌(Adenocarcinoma);胰岛素样生长因子Ⅱ(Insulin-Like Growth Factor II);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);细胞系, 肿瘤(Cell Line, Tumor);男(雄)性(Male);上皮-间质转化(Epithelial-Mesenchymal Transition);小鼠, 裸(Mice, Nude);细胞运动(Cell Movement);女(雌)性(Female);小鼠, 近交BALB C(Mice, Inbred BALB C)

DOI 10.1038/s41416-025-03017-1

PMID 40301686

发布时间 2026-04-30

检索历史清除

POU6F2 promotes liver metastasis of gastric adenocarcinoma by dual mechanism of transcriptional upregulation of SNAI1 and IGF2/PI3K/AKT signaling-induced conversion of hepatic stellate cells into cancer-associated fibroblasts.

British journal of cancer

相似文献

同项目论文

British journal of cancer

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

POU6F2 promotes liver metastasis of gastric adenocarcinoma by dual mechanism of transcriptional upregulation of SNAI1 and IGF2/PI3K/AKT signaling-induced conversion of hepatic stellate cells into cancer-associated fibroblasts.

British journal of cancer

相似文献

同项目论文

British journal of cancer

相关期刊

检索历史清除