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Synergistic enhancement of PARP inhibition via small molecule UNI66-mediated suppression of BRD4-dependent transcription of RAD51 and CtIP.

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第一作者： Enkhzul,Amarsanaa

第一单位： Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.;Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.

作者： Enkhzul,Amarsanaa ^[1] ; Minwoo,Wie ^[1] ; Unbeom,Shin ^[2] ; Nabeela,Bilal ^[3] ; Jungme,Hwang ^[2] ; Eun A,Lee ^[2] ; Seon Young,Lee ^[2] ; Byung-Gyu,Kim ^[2] ; Shinseog,Kim ^[2] ; Yoonsung,Lee ^[4] ; Kyungjae,Myung ^[3]

作者单位： Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.;Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. ^[1] Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea. ^[2] Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.;Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. ^[3] Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea. ^[4]

医学主题词人类(Humans);转录因子(Transcription Factors);Rad51重组酶(Rad51 Recombinase);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);药物协同作用(Drug Synergism);转录, 遗传(Transcription, Genetic);减量调节(Down-Regulation);核蛋白质类(Nuclear Proteins);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)

DOI 10.1093/narcan/zcaf013

PMID 40308947

发布时间 2025-05-02

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Synergistic enhancement of PARP inhibition via small molecule UNI66-mediated suppression of BRD4-dependent transcription of <i>RAD51</i> and <i>CtIP</i>.

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Synergistic enhancement of PARP inhibition via small molecule UNI66-mediated suppression of BRD4-dependent transcription of <i>RAD51</i> and <i>CtIP</i>.

NAR cancer

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NAR cancer

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