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Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study.

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第一作者： Rubina,Sharma

第一单位： Oral Immunobiology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD.

作者： Rubina,Sharma ^[1] ; Noa G,Holtzman ^[2] ; Iskra,Pusic ^[3] ; Corey,Cutler ^[4] ; Nathaniel,Treister ^[5] ; Rohtesh S,Mehta ^[6] ; Amin S,Alousi ^[7] ; Nadarajah,Vigneswaran ^[8] ; Ayesha,Javaid ^[1] ; Francis,Boksa ^[1] ; Drashty P,Mody ^[1] ; Ana C,Costa-da-Silva ^[1] ; Olivier,Schueller ^[9] ; Sandrine,Macé ^[10] ; Yu,Yao ^[9] ; Ran,Ji ^[11] ; Beifang,Hu ^[11] ; Kathy,Marshall ^[11] ; Bruce R,Blazar ^[12] ; Stephanie J,Lee ^[6] ; Steven Z,Pavletic ^[2] ; Jacqueline W,Mays ^[1]

作者单位： Oral Immunobiology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD. ^[1] Immune Deficiency Cellular Therapy Program, National Cancer Institute, National Institutes of Health, Bethesda, MD. ^[2] Division of Oncology, Washington University School of Medicine, St. Louis, MO. ^[3] Division of Transplantation and Cellular Therapy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. ^[4] Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA. ^[5] Division of Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA. ^[6] Division of Cancer Medicine, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX. ^[7] Department of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center, School of Dentistry, Houston, TX. ^[8] Sanofi, Cambridge, MA. ^[9] Sanofi, Vitry-Sur-Seine, France. ^[10] Sanofi, Bridgewater, NJ. ^[11] Division of Blood and Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota, Minneapolis, MN. ^[12]

医学主题词成年人(Adult);老年人(Aged);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);慢性病(Chronic Disease);纤维化(Fibrosis);移植物抗宿主病(Graft vs Host Disease);炎症(Inflammation);白细胞介素17(Interleukin-17);口腔黏膜(Mouth Mucosa);蛋白激酶抑制剂(Protein Kinase Inhibitors);rho相关激酶类(rho-Associated Kinases)

DOI 10.1182/bloodadvances.2025016170

PMID 40311075

发布时间 2025-07-22

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Blood advances

2025年9卷14期

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Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study.

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Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study.

Blood advances

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Blood advances

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