首页> Journal for immunotherapy of cancer> B4GALT5 inhibits CD8<sup>+</sup> T-cell response by downregulating MHC-I level through ERAD pathway in PDAC.

B4GALT5 inhibits CD8<sup>+</sup> T-cell response by downregulating MHC-I level through ERAD pathway in PDAC.

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第一作者： Xin,Xing

第一单位： Shanghai Fengxian District Central Hospital, School of Medicine, Anhui University of Science and Technology, Shanghai, China.;Shanghai University of Medicine and Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, China.

作者： Xin,Xing ^[1] ; Shi-Qi,Yin ^[2] ; Xia-Qing,Li ^[2] ; Hui,Li ^[3] ; Hong-Tai,Ma ^[2] ; Aziguli,Tulamaiti ^[3] ; Shu-Yu,Xiao ^[3] ; Yu-Tong,Liu ^[4] ; Hao,Zhang ^[5] ; Zhigang,Zhang ^[3] ; Yan-Miao,Huo ^[6] ; Xiao-Mei,Yang ^[7] ; Yan,Yang ^[7] ; Xue-Li,Zhang ^[8]

作者单位： Shanghai Fengxian District Central Hospital, School of Medicine, Anhui University of Science and Technology, Shanghai, China.;Shanghai University of Medicine and Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, China. ^[1] Shanghai Fengxian District Central Hospital, School of Medicine, Anhui University of Science and Technology, Shanghai, China. ^[2] State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[3] The First Hospital of Jilin University, Changchun, Jilin, China. ^[4] Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[5] Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China xlzhang@shsci.org yangyang201298@163.com xmyang@shsci.org huoyanmiao@126.com. ^[6] State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China xlzhang@shsci.org yangyang201298@163.com xmyang@shsci.org huoyanmiao@126.com. ^[7] Shanghai University of Medicine and Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, China xlzhang@shsci.org yangyang201298@163.com xmyang@shsci.org huoyanmiao@126.com.;State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[8]

关键词 Immunotherapy Major histocompatibility complex - MHC T cell Tumor microenvironment - TME