首页> Experimental hematology & oncology> IL-6-mediated tumorigenicity and antioxidant state in squamous cell carcinoma cells are driven by CD109 via stabilization of IL-6 receptor-alpha and activation of STAT3/NRF2 pathway.

IL-6-mediated tumorigenicity and antioxidant state in squamous cell carcinoma cells are driven by CD109 via stabilization of IL-6 receptor-alpha and activation of STAT3/NRF2 pathway.

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第一作者： Amani,Hassan

第一单位： Divisions of Plastic Surgery, and Surgical and Interventional Sciences, Department of Surgery, McGill University, Montreal, QC, Canada.

作者： Amani,Hassan ^[1] ; Tenzin,Kungyal ^[1] ; Shufeng,Zhou ^[1] ; Meryem,Blati ^[1] ; Kenneth,Finnson ^[1] ; Nick,Bertos ^[2] ; Nahid,Golabi ^[3] ; Nader,Sadeghi ^[3] ; Sampath,Loganathan ^[3] ; Anie,Philip ^[4]

作者单位： Divisions of Plastic Surgery, and Surgical and Interventional Sciences, Department of Surgery, McGill University, Montreal, QC, Canada. ^[1] Divisions of Thoracic and Upper GI Surgery, Department of Surgery, McGill University, Montreal, QC, Canada. ^[2] Department of Otolaryngology, Head and Neck Surgery, and Division of Experimental Medicine, McGill University Health Center, Montreal, QC, Canada. ^[3] Divisions of Plastic Surgery, and Surgical and Interventional Sciences, Department of Surgery, McGill University, Montreal, QC, Canada. anie.philip@mcgill.ca.;Divisions of Dermatology and Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, Canada. anie.philip@mcgill.ca.;Montreal General Hospital, 1650 Cedar Avenue, Room C10-148.4, Montreal, QC, H3G 1A4, Canada. anie.philip@mcgill.ca. ^[4]

关键词 Antioxidant pathway CD109 IL6Rα NRF2 STAT3 Squamous cell ?carcinoma Stemness

DOI 10.1186/s40164-025-00630-x

PMID 40317079

发布时间 2025-06-03

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