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Multiomic profiling of glioblastoma metabolic lesions reveals complex intratumoral genomic evolution and dipeptidase-1-driven vascular proliferation.

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第一作者： Atul,Anand

第一单位： Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.;Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.;Department of Clinical Research, University of Southern Denmark, Odense, Denmark.;Department of Pathology, Odense University Hospital, Odense, Denmark.

作者： Atul,Anand ^[1] ; Jeanette Krogh,Petersen ^[2] ; Lars van Brakel,Andersen ^[3] ; Mark,Burton ^[3] ; Clara Rosa Levina,Oudenaarden ^[4] ; Martin Jakob,Larsen ^[3] ; Philip Ahle,Erichsen ^[4] ; Christian Bonde,Pedersen ^[5] ; Frantz Rom,Poulsen ^[5] ; Peter,Grupe ^[6] ; Torben A,Kruse ^[3] ; Mads,Thomassen ^[3] ; Bjarne Winther,Kristensen ^[1]

作者单位： Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.;Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark.;Department of Clinical Research, University of Southern Denmark, Odense, Denmark.;Department of Pathology, Odense University Hospital, Odense, Denmark. ^[1] Department of Pathology, Odense University Hospital, Odense, Denmark. ^[2] Clinical Genome Center, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.;Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. ^[3] Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.;Department of Clinical Medicine and Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark. ^[4] BRIDGE, Brain Research - Inter Disciplinary Guided Excellence, Odense University Hospital and University of Southern Denmark, Odense, Denmark.;Department of Neurosurgery, Odense University Hospital, Odense, Denmark.;Department of Clinical Research, University of Southern Denmark, Odense, Denmark. ^[5] Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. ^[6]

关键词 dipeptidase 1 hypermetabolism mutational burden tumor evolution vascular tip