首页> Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine> Evaluation of the distribution of the boron neutron capture therapy drug 4-borono-L-phenylalanine (BPA) in a rat brain tumor model using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Evaluation of the distribution of the boron neutron capture therapy drug 4-borono-L-phenylalanine (BPA) in a rat brain tumor model using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

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第一作者： Sachie,Kusaka

第一单位： Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, 565-0871, Osaka, Japan. Electronic address: kusaka@see.eng.osaka-u.ac.jp.

作者： Sachie,Kusaka ^[1] ; Yumi,Miyake ^[2] ; Yugo,Tokumaru ^[3] ; Nikolaos,Voulgaris ^[4] ; Isao,Murata ^[5]

作者单位： Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, 565-0871, Osaka, Japan. Electronic address: kusaka@see.eng.osaka-u.ac.jp. ^[1] Forefront Research Center, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, 560-0043, Osaka, Japan; Core Facility Center, Osaka University, 1-2 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan. Electronic address: miyake.yumi.corefc@osaka-u.ac.jp. ^[2] Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, 565-0871, Osaka, Japan. Electronic address: tokumaru@qb.see.eng.osaka-u.ac.jp. ^[3] Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, 565-0871, Osaka, Japan. Electronic address: Voulgaris.Nikolaos@qr.see.eng.osaka-u.ac.jp. ^[4] Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, 565-0871, Osaka, Japan. Electronic address: murata@see.eng.osaka-u.ac.jp. ^[5]

关键词 4-Borono-L-phenylalanine (BPA)Blood brain barrier (BBB)Boron neutron capture therapy (BNCT)Brain tumor Liquid chromatography/mass spectrometry (LC/MS)Quantification of drug uptake heterogeneity Rat melanoma model